Abstract | PURPOSE: METHODS: RESULTS: The range of mean in vitro EC50 concentrations for each antiviral across the range of HAdV types is as follows: The positive antiviral control, CDV, ranged from 0.47 to 9.62 µM; REM ranged from 0.21 to 11.27 µM; UMF ranged from 3.72 to 64.8 µM; IVR ranged from 2.60 to 201.3 µM; and HCQ was >10 µM for all Ad types because of toxicity to the A549 cells. REM produced lower EC50 concentrations than CDV for 6 of 7 HAdV types. Potency increases with lower EC50 concentrations. CONCLUSION: REM demonstrated anti-adenovirus activity in a range similar to that demonstrated by cidofovir. UMF and IVR demonstrated larger ranges of antiviral activity than CDV and REM across the panel of HAdV types. The anti-adenovirus activity of HCQ could not be determined due to cytotoxicity. Further investigation of REM, UMF, and IVR as antivirals for adenovirus is indicated.
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Authors | Eric G Romanowski, Kathleen A Yates, John E Romanowski, Robert M Q Shanks, Regis P Kowalski |
Journal | Clinical ophthalmology (Auckland, N.Z.)
(Clin Ophthalmol)
Vol. 15
Pg. 4787-4793
( 2021)
ISSN: 1177-5467 [Print] New Zealand |
PMID | 35221670
(Publication Type: Journal Article)
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Copyright | © 2021 Romanowski et al. |