Abstract | BACKGROUND: Mitochondrial participation in tumorigenesis and metastasis has been studied for many years, but several aspects of this mechanism remain unclear, such as the association of mitochondrial DNA ( mtDNA) with different cancers. Here, based on two independent datasets, we modelled an mtDNA mutation- cancer network by systematic integrative analysis including 37 cancer types to identify the mitochondrial variants found in common among them. RESULTS: Our network showed mtDNA associations between gastric cancer and other cancer types, particularly kidney, liver, and prostate cancers, which is suggestive of a potential role of such variants in the metastatic processes among these cancer types. A graph-based interactive web tool was made available at www2.lghm.ufpa.br/ mtdna. We also highlighted that most shared variants were in the MT-ND4, MT-ND5 and D-loop, and that some of these variants were nonsynonymous, indicating a special importance of these variants and regions regarding cancer progression, involving genomic and epigenomic alterations. CONCLUSIONS: This study reinforces the importance of studying mtDNA in cancer and offers new perspectives on the potential involvement of different mitochondrial variants in cancer development and metastasis.
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Authors | Giovanna C Cavalcante, Ândrea Ribeiro-Dos-Santos, Gilderlanio S de Araújo |
Journal | BMC genomic data
(BMC Genom Data)
Vol. 23
Issue 1
Pg. 16
(02 18 2022)
ISSN: 2730-6844 [Electronic] England |
PMID | 35183124
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s). |
Chemical References |
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Topics |
- DNA, Mitochondrial
(genetics)
- Humans
- Male
- Mitochondria
(genetics)
- Neoplastic Processes
- Stomach Neoplasms
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