Abstract | BACKGROUND:
Cilostazol combined with P2Y12 receptor inhibitor has been used as a substitute regimen for aspirin-intolerant patients undergoing percutaneous coronary stent implantation on a small scale. Its exact impact on platelet functions and clinical benefits of aspirin-intolerant patients is unknown. HYPOTHESIS:
Cilostazol combined with P2Y12 receptor inhibitors could be used as a substitute antiplatelet regimen for aspirin-intolerant patients undergoing percutaneous coronary stent implantation. METHODS: RESULTS: One hundred and fifty-four aspirin-intolerant percutaneous coronary stent implantation patients and 154 matched aspirin-tolerant patients from a total of 2059 percutaneous coronary stent implantation patients were enrolled. The relative activation level of PAC-1, CD62p, and platelet reaction index reflected by the VASP-P test were similar in the two groups (p > .05). After 12 months of follow-up, the incidence of all-cause death was 1.9% in the cilostazol group and 1.3% in the aspirin group (risk ratio [RR], 1.500; 95% confidence interval [CI], 0.254-8.852; p = 1.000); the incidence of acute myocardial infarction was 0.6% in the cilostazol group and 1.3% in the aspirin group (RR, 0.500; 95% CI, 0.046-5.457; p = 1.000). No significant difference was seen in other MACCE events, or in any types of BARC bleeding events. CONCLUSIONS:
Cilostazol combined with P2Y12 inhibitors was not inferior to aspirin-based standard therapy and could be used as a reasonable substitute antiplatelet regimen for aspirin-intolerant patients undergoing percutaneous coronary stent implantation, but again with limitations, which required a larger sample and longer follow-up to confirm its efficacy.
|
Authors | Yikai Zhao, Peng Zhou, Wen Gao, Haoxuan Zhong, Yufei Chen, Wei Chen, Maieryemu Waresi, Kun Xie, Haiming Shi, Hui Gong, Guibin He, Zhaohui Qiu, Xinping Luo, Jian Li |
Journal | Clinical cardiology
(Clin Cardiol)
Vol. 45
Issue 2
Pg. 189-197
(Feb 2022)
ISSN: 1932-8737 [Electronic] United States |
PMID | 35120275
(Publication Type: Journal Article, Multicenter Study)
|
Copyright | © 2022 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC. |
Chemical References |
- Platelet Aggregation Inhibitors
- Cilostazol
- Aspirin
|
Topics |
- Aspirin
(adverse effects)
- Cilostazol
(adverse effects)
- Drug Therapy, Combination
- Drug-Eluting Stents
- Humans
- Percutaneous Coronary Intervention
(adverse effects)
- Platelet Aggregation Inhibitors
(adverse effects)
- Prospective Studies
- Stents
- Treatment Outcome
|