Abstract | BACKGROUND: METHODS: Oncomine database was used to determine the differential expression of BUB1 in normal and lung adenocarcinoma tissues, while UALCAN was used to perform analysis of the relative expression and survival of BUB1 between tumor and normal tissues in different tumor subgroups. We used the cBioPortal for Cancer Genomics to perform gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the top 50 altered neighbor genes of BUB1. The LinkedOmics database was used to determine differential gene expression with BUB1 and to perform functional analysis. The kinase, miRNA and transcription factor target networks correlated with BUB1 were also analyzed by LinkedOmics database. RESULTS: CONCLUSIONS: Our study analyzed BUB1 expression and potential gene regulation networks in lung adenocarcinoma based on bioinformatics analysis, guiding further study on the role and regulation of BUB1 in lung adenocarcinoma. BUB1 may hopefully become a novel marker and therapeutic target for lung adenocarcinoma.
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Authors | Luyao Wang, Xue Yang, Ning An, Jia Liu |
Journal | Translational cancer research
(Transl Cancer Res)
Vol. 9
Issue 8
Pg. 4820-4833
(Aug 2020)
ISSN: 2219-6803 [Electronic] China |
PMID | 35117845
(Publication Type: Journal Article)
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Copyright | 2020 Translational Cancer Research. All rights reserved. |