High-dose oral terbinafine in the treatment of pediatric tinea capitis under 2 years old.

Abstract

Tinea capitis is the most common pediatric dermatophytosis of the scalp and hair follicles that require oral antifungals therapy. It usually occurs in children between 3 and 7 years old, whereas it is rarely reported in children under 2 years old. Although oral terbinafine has been broadly used to treat tinea capitis, it is not approved for pediatric patients under 2 years old. Previous studies reported that a doubled oral terbinafine dose could improve the cure rates of tinea capitis due to Microsporum canis. However, the doses are all not strictly weight-based. Here, we report four pediatric tinea capitis patients under 2 years of age who were treated with a high, strictly weight-based dose of oral terbinafine therapy (10 mg/kg/day). We determine the efficacy and safety of this novel oral terbinafine therapy schedule. It may be a promising therapy to treat pediatric tinea capitis under 2 years old.

• Authors: Ya Bin Zhou, Jin Jing Chao, Yuan Yuan Xiao, Lin Ma
• Journal: Dermatologic therapy (Dermatol Ther) Vol. 35 Issue 4 Pg. e15320 (04 2022) ISSN: 1529-8019 [Electronic] United States
• PMID: 35038221 (Publication Type: Journal Article)
• Copyright: © 2022 Wiley Periodicals LLC.

Chemical References

• Antifungal Agents
• Naphthalenes
• Terbinafine

Topics

• Administration, Oral
• Antifungal Agents
• Child
• Child, Preschool
• Humans
• Infant
• Naphthalenes
• Terbinafine
• Tinea Capitis (diagnosis, drug therapy)
• Treatment Outcome