Tinea Capitis

Ringworm of the scalp and associated hair mainly caused by species of MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON, which may occasionally involve the eyebrows and eyelashes.

Also Known As:

Tinea Capitis Profunda; Trichophytia Profunda Barbae; Trichophytia Profunda Capitis; Barbae, Trichophytia Profunda; Capitides, Trichophytia Profunda; Capitis Profunda, Tinea; Capitis Profundas, Tinea; Capitis, Trichophytia Profunda; Profunda Barbae, Trichophytia; Profunda Capitides, Trichophytia; Profunda Capitis, Trichophytia; Profunda, Tinea Capitis; Profundas, Tinea Capitis; Tinea Capitis Profundas; Trichophytia Profunda Capitides; Kerion Celsi

Networked: 507 relevant articles (78 outcomes, 72 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Tinea (Ringworm)
2.	Mycoses (Diseases, Fungus)
3.	Trichophyton infection
4.	Onychomycosis (Tinea Unguium)
5.	Tinea Versicolor (Pityriasis Versicolor)

Experts

1.	Gupta, Aditya K: 14 articles (07/2021 - 04/2002)
2.	Cooper, Elizabeth A: 6 articles (11/2008 - 07/2003)
3.	Nenoff, Pietro: 5 articles (07/2021 - 07/2014)
4.	Boaventura, Paula: 5 articles (01/2018 - 03/2012)
5.	Soares, Paula: 5 articles (01/2018 - 03/2012)
6.	Gupta, A K: 5 articles (11/2003 - 05/2000)
7.	Chao, Jin Jing: 4 articles (01/2022 - 01/2021)
8.	Ma, Lin: 4 articles (01/2022 - 01/2021)
9.	Xiao, Yuan Yuan: 4 articles (01/2022 - 01/2021)
10.	Zhou, Ya Bin: 4 articles (01/2022 - 01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tinea Capitis:

1.	Terbinafine (Lamisil)FDA LinkGeneric 07/01/1996 - "In our opinion, terbinafine given for 1, 2 or 4 weeks, is equally effective for most cases of tinea capitis." 01/01/1999 - "Terbinafine was thought to be very effective and safe for kerion Celsi. " 10/01/2021 - "We conclude that both drugs were effective for the treatment of tinea capitis; however, lesions in those cases receiving terbinafine involuted more slowly." 11/01/2020 - "This preliminary study demonstrated that topical 1% encapsulated terbinafine hydrochloride gel was an effective treatment for tinea capitis in children." 11/01/2020 - "We evaluated the therapeutic efficacy, safety, and tolerability of topical 1% encapsulated terbinafine hydrochloride gel for the treatment of pediatric tinea capitis. "
2.	Griseofulvin (Grifulvin V)FDA LinkGeneric 10/01/2013 - "We report a case of severe tinea capitis, treated successfully with griseofulvin. " 03/01/2010 - "To describe (a) the predictive value of symptoms for diagnosis of tinea capitis and (b) the rate and timing of cure with high-dose griseofulvin treatment. " 12/01/2015 - "With introduction of Griseofulvin in 1958, there has been considerable improvement in the treatment of tinea capitis. " 01/01/2021 - "Trichophyton tonsurans is the predominant cause of tinea capitis in the USA, although the main gold standard of treatment in the USA is griseofulvin. " 01/01/1962 - "A controlled field trial in Yugoslavia of the efficacy of griseofulvin in the mass treatment of tinea capitis."
3.	Itraconazole (Sporanox)FDA LinkGeneric 11/01/2001 - "Itraconazole is effective in the treatment of tinea capitis caused by Microsporum canis." 10/01/2009 - "Itraconazole proved to be a safe and effective treatment option for Microsporum canis induced tinea capitis in children in their first year of life." 05/01/1998 - "This information would then be useful in determining the efficacy of itraconazole administered by means of intermittent pulse dosing in the treatment of tinea capitis. " 09/01/1990 - "Low-dose itraconazole appears to be safe and effective in the treatment of tinea capitis." 11/01/2015 - "We report a case of pediatric tinea capitis cured using oral itraconazole administered with whole milk, after prior treatment failure when oral itraconazole was administered with water. "
4.	Fluconazole (Zonal)FDA LinkGeneric 05/01/2000 - "Once weekly fluconazole is effective in children in the treatment of tinea capitis: a prospective, multicentre study." 01/01/2002 - "Fluconazole was effective in treating pediatric tinea capitis caused by Microsporum canis and was well tolerated. " 05/01/2000 - "In an open, multicentre evaluation carried out in Brazil, Canada and South Africa we have demonstrated that fluconazole 8 mg kg-1 once weekly is effective in tinea capitis caused by Trichophyton and Microsporum species. " 11/01/2005 - "Fluconazole is one such treatment option, and a variety of studies using this drug have shown promise in the treatment of pediatric tinea capitis. " 11/01/2005 - "A randomized controlled trial assessing the efficacy of fluconazole in the treatment of pediatric tinea capitis."
5.	Antifungal AgentsIBA 03/01/2018 - "The aim of the study was to investigate the most prevalent fungal species causing tinea capitis in children from Egypt and the most useful antifungal agent for treatment. " 01/01/2023 - "For treatment of kerion celsi, we chose an oral antifungal agent, fosravuconazole (FRVCZ), which has been available since 2018 only in Japan. " 01/01/2021 - "Tinea capitis is faced with therapeutic challenges as resistance to all classes of antifungal agents continues to emerge. " 07/01/2014 - "species of Arthroderma benhamiae, in particular of tinea capitis, requires oral antifungal agents. " 05/01/2010 - "Tinea capitis always requires systemic treatment because topical antifungal agents do not penetrate the hair follicle. "
6.	Ketoconazole (Nizoral)FDA LinkGeneric 04/01/2000 - "The purpose of this open study was to evaluate ketoconazole 2% shampoo as a monotherapy for the treatment of tinea capitis. " 07/01/2011 - "Patients at high risk for tinea capitis received twice-weekly ketoconazole shampoo. " 07/01/2011 - "Prophylactic ketoconazole shampoo for tinea capitis in a high-risk pediatric population." 04/01/2000 - "Ketoconazole 2% shampoo alone reduces the number of viable arthroconidia in children with tinea capitis thus reducing the transmissibility and contagious nature of the disease. " 04/01/2000 - "A total of 16 black children, aged 3-6, all with proven tinea capitis caused by Trichophyton tonsurans, were treated daily for 8 weeks with 2% ketoconazole shampoo for a total of 56 treatments. "
7.	SuspensionsIBA 04/01/1997 - "California Medi-Cal provider data for first-time prescriptions of oral griseofulvin suspension were used to estimate annual incidence of tinea capitis and calculate risk ratios. " 07/01/2012 - "Of the 80 tinea capitis patients initially treated with griseofulvin, 41 out of 54 children (76%) had complete response to micronized suspension +/- crushed tablet (33% required shift to tablets from suspension) and 20 out of 26 (76.9%) cleared on crushed tablets alone. " 11/01/2001 - "Itraconazole 5 mg/kg/day given either as a capsule or an oral suspension for 4-8 weeks is effective and safe in the treatment of tinea capitis caused by M. " 07/01/2008 - "Terbinafine hydrochloride oral granules versus oral griseofulvin suspension in children with tinea capitis: results of two randomized, investigator-blinded, multicenter, international, controlled trials." 07/01/2008 - "To compare the efficacy and safety of a new pediatric formulation of terbinafine hydrochloride oral granules with griseofulvin oral suspension in the treatment of tinea capitis. "
8.	selenium disulfide (Head & Shoulders)FDA LinkGeneric 07/01/1995 - "Comparison of 1% and 2.5% selenium sulfide in the treatment of tinea capitis." 01/01/1982 - "Selenium sulfide: adjunctive therapy for tinea capitis." 07/01/1995 - "To determine whether an over-the-counter shampoo containing 1% selenium sulfide would have sporicidal activity equal to that of a 2.5% selenium sulfide prescription lotion in the adjunctive treatment of tinea capitis infection. " 07/01/1995 - "Commercially available 1% selenium sulfide shampoo is an equally effective yet less expensive alternative sporicidal therapy in the adjunctive treatment of tinea capitis infection." 09/01/2010 - "Our objective was to compare the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. "
9.	Ointments (Pastes)IBA 10/01/1956 - "Tinea capitis due to Microsporum audouini: treatment with new improved Salundek ointment and Salundek lotion." 05/01/1953 - "Convulsions following treatment of tinea capitis with asterol dihydrochloride ointment." 05/01/1953 - "Convulsions following treatment of tinea capitis with asterol dihydrochloride ointment; report of a case." 01/01/1797 - "The History of an Inveterate Case of Tinea Capitis, Successfully Treated by the Application of an Adhesive Paste." 03/01/1948 - "Tinea capitis, benefited by an iodine ointment."
10.	TabletsIBA 09/01/1998 - "Efficacy, safety and tolerability of terbinafine for Tinea capitis in children: Brazilian multicentric study with daily oral tablets for 1,2 and 4 weeks." 07/01/2012 - "Of the 80 tinea capitis patients initially treated with griseofulvin, 41 out of 54 children (76%) had complete response to micronized suspension +/- crushed tablet (33% required shift to tablets from suspension) and 20 out of 26 (76.9%) cleared on crushed tablets alone. " 09/01/1999 - "The availability of the oral solution will enable more young children to be considered for treatment of tinea capitis with itraconazole than was possible when only tablets or capsules were available." 01/01/2021 - "Species identification was confirmed by matrix-assisted laser desorption-ionization-time of flight mass spectrometry (MALDI-TOF MS) and the patient was treated for kerion celsi with terbinafine tablets 125 mg per day associated with a ketoconazole-based shampoo. " 09/01/2001 - "The regimens for treating tinea capitis were griseofulvin microsize 20 mg/kg/day x 6 weeks, terbinafine [> 40 kg, one 250 mg tablet; 20-40 kg, 125 mg (half of a 250 mg tablet); < 20 kg, 62.5 mg (one-quarter of a 250 mg tablet)] x 2-3 weeks, itraconazole 5 mg/kg/day x 2-3 weeks, and fluconazole 6 mg/kg/day x 2-3 weeks. "

Therapies and Procedures

1.	Therapeutics 09/29/2023 - "Conclusions This study found that diagnostic testing, dual therapy, and SDOH diagnostic codes were underutilized for pediatric patients diagnosed with tinea capitis. " 09/17/2023 - "In this study, 37 patients treated for acquired defects of the scalp with a history of irradiation therapy due to tinea capitis in childhood were included in this study, 24 male and 13 female patients. " 10/17/2007 - "Randomised controlled trials (RCTs) that evaluated systemic antifungal therapy in people with normal immunity under the age of 18 who had tinea capitis confirmed by microscopy or growth of dermatophytes in culture or both. " 05/01/1952 - "A study of topical therapy in Tinea capitis." 01/01/2022 - "It may be a promising therapy to treat pediatric tinea capitis under 2 years old."
2.	Duration of Therapy 05/01/1995 - "The median treatment was 4 weeks, the duration of treatment in the tinea capitis studies. " 05/01/2002 - "However, the optimal treatment duration for its use in the treatment of tinea capitis caused by Microsporum species has not yet been determined. " 05/01/1995 - "The recommended duration of treatment for tinea capitis is 4 weeks.(ABSTRACT TRUNCATED AT 250 WORDS)" 11/09/2023 - "Oral antifungal drugs are considered the first-line treatment for tinea capitis; however, drugs therapy is challenged by the long treatment duration, side effects, and drug resistance. " 09/01/1990 - "Therapy duration was as follows: tinea corporis and tinea cruris, 14 days; tinea pedis and tinea manuum, 28 days; tinea unguium of hands, three months, and feet, six months; tinea capitis, 30 days. "
3.	Radiotherapy 06/01/2021 - "We present a 93-year-old woman with 4 BCCs of the scalp after radiotherapy for tinea capitis, diagnosed after a latency period of over 80 years. " 01/01/2021 - "We developed a statistical model, encompassing gains in 3p and 16p and losses in 14q and 20p, with potential to discriminate BCC samples with sporadic aetiology from BCC samples that evolve after radiotherapy in childhood for the treatment of tinea capitis, which presented statistical significance (P = 0.003). " 07/01/2018 - "BCCs following radiation therapy for tinea capitis show unique histological characteristics related to aggressive behaviour. " 04/01/2015 - "The treatment of tinea capitis using radiotherapy was introduced at the beginning of the twentieth century. " 07/01/2013 - "Patients with history of radiotherapy for the treatment of tinea capitis in childhood showed less response (P < 0.05). "
4.	Aftercare (After-Treatment) 01/01/2008 - "Tinea capitis was cured in 4 months after treatment. " 11/01/2006 - "Report of clinical and microbiological periodontal findings before and 6 months after treatment of two siblings with Papillon-Lefèvre syndrome (PLS) and tinea capitis. " 01/03/1959 - "[Results in treatment & follow-up care of tinea capitis in 30 years]." 08/01/1954 - "A survey of tinea capitis five years after treatment by x-ray epilation." 03/04/2010 - "Finally, the successful treatment of tinea capitis with griseofulvin by Gentles in 1958 saved many patients with tinea capitis from permanent hair loss, a common side effect after treatment with thallium. "
5.	X-Ray Therapy 10/01/2006 - "It is concluded that BCC of the scalp following X-ray therapy for tinea capitis have some clinical and histological particularities. " 07/01/1982 - "Between 1950 and 1960 about 20,000 israeli children were treated for tinea capitis by x-ray therapy as part of a large public health campaign to eradicate the disease. " 01/01/1976 - "This is the second follow-up study of 2,215 persons who during childhood between 1940 and 1959 had been given x-ray therapy for tinea capitis and of 1,395 persons well matched for age, sex, and race who were treated for the same disease during the same period without the use of x-ray therapy. " 04/01/1968 - "Doses to brain, skull and thyroid, following x-ray therapy for Tinea capitis." 06/19/1952 - "[Comments on x-ray therapy of kerion celsi]."