Abstract | BACKGROUND: METHODS: 120 MHD patients were recruited at Department of Nephrology, Zhongnan Hospital of Wuhan University to analyze the expression of genotype, allele and haplotype of Fok I, Bsm I, Apa I and Taq I in blood samples, and to explore their correlation with blood biochemical indexes and ventricular remodeling. RESULTS: The results showed that the risks of CVD included gender, dialysis time, heart rate, SBP, glycated hemoglobin, calcium, iPTH and CRP concentration. Moreover, LAD, LVDd, LVDs, IVST and LVMI in B allele of Bsm I increased significantly. Fok I, Apa I and Taq I polymorphisms have no significant difference between MHD with LVH and without LVH. Further study showed that VDR expression level decreased significantly in MHD patients with LVH, and the B allele was positively correlated with VDR Expression. CONCLUSION: VDR Bsm I gene polymorphism may predict cardiovascular disease risk of MDH patients, and provided theoretical basis for early detection and prevention of cardiovascular complications.
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Authors | Bingman Liu, Qingqing Yang, Liangyu Zhao, Hua Shui, Xiaoyun Si |
Journal | BMC nephrology
(BMC Nephrol)
Vol. 23
Issue 1
Pg. 32
(01 15 2022)
ISSN: 1471-2369 [Electronic] England |
PMID | 35033017
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Receptors, Calcitriol
- VDR protein, human
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Topics |
- Adult
- China
- Female
- Humans
- Hypertrophy, Left Ventricular
(genetics)
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Prognosis
- Receptors, Calcitriol
(genetics)
- Renal Dialysis
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