Abstract |
COVID-19 has caused a global pandemic and millions of deaths. It is imperative to develop effective countermeasures against the causative viral agent, SARS-CoV-2 and its many variants. Vaccines and therapeutic antibodies are the most effective approaches for preventing and treating COVID-19, respectively. SARS-CoV-2 enters host cells through the activities of the virus-surface spike (S) protein. Accordingly, the S protein is a prime target for vaccines and therapeutic antibodies. Dealing with particles with dimensions on the scale of nanometers, nanotechnology has emerged as a critical tool for rapidly designing and developing safe, effective, and urgently needed vaccines and therapeutics to control the COVID-19 pandemic. For example, nanotechnology was key to the fast-track approval of two mRNA vaccines for their wide use in human populations. In this review article, we first explore the roles of nanotechnology in battling COVID-19, including protein nanoparticles (for presentation of protein vaccines), lipid nanoparticles (for formulation with mRNAs), and nanobodies (as unique therapeutic antibodies). We then summarize the currently available COVID-19 vaccines and therapeutics based on nanotechnology.
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Authors | Lanying Du, Yang Yang, Xiujuan Zhang, Fang Li |
Journal | Nanoscale
(Nanoscale)
Vol. 14
Issue 4
Pg. 1054-1074
(Jan 27 2022)
ISSN: 2040-3372 [Electronic] England |
PMID | 35018939
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies
- COVID-19 Vaccines
- Lipid Nanoparticles
- Liposomes
- mRNA Vaccines
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Topics |
- Antibodies
(therapeutic use)
- COVID-19
(prevention & control, therapy)
- COVID-19 Vaccines
- Humans
- Liposomes
- Nanoparticles
- Nanotechnology
- Pandemics
- mRNA Vaccines
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