Abstract | BACKGROUND: The variable visual function observed in diabetic retinopathy (DR) patients is not fully explained by the classic staging system. Our purpose was to evaluate choroidal changes, in standardized sectors, in DR patients and to find associations between choroidal measurements and visual function. METHODS: Cross-sectional study that included the right eye of diabetic patients (n = 265) without active edema, ischemia or neovascularization and age-matched controls (n = 73). Optical coherence tomography (OCT) imaging was performed with enhanced depth imaging protocol. Choroidal vascularity index (CVI) was calculated in a 5 mm scan centered in the fovea. RESULTS: CVI decreased with age (p < 0.001) but was not influenced by axial length. A multivariate analysis adjusting for age confirmed a significant difference in CVI between DR eyes that had previous treatments ( intravitreal injections and/or photocoagulation) compared to control eyes (p = 0.013) and to DR eyes that never required treatment (p = 0.002). There was no significant difference between non-DR diabetic patients and normal controls. Considering the group of DR patients that had previous treatments, in eyes without optic media opacification, BCVA correlated with CVI (r = - 0.362, p < 0.001), whereas full retina thickness and individual retinal layer thickness did not (p > 0.066). CONCLUSIONS: TRIAL REGISTRATION: N/A.
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Authors | João Heitor Marques, Ana Marta, Catarina Castro, Pedro Manuel Baptista, Diana José, Daniel Almeida, António Ribeiro, Irene Barbosa |
Journal | International journal of retina and vitreous
(Int J Retina Vitreous)
Vol. 8
Issue 1
Pg. 6
(Jan 08 2022)
ISSN: 2056-9920 [Print] England |
PMID | 34998439
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s). |