Colonic Metastasis from Breast Cancer: A Case Report and Review of the Literature.

Abstract

BACKGROUND:

Breast cancer often metastasizes to the lungs, bones, liver, and brain, colon metastasis from breast cancer (CMBC) is extremely rare.

CASE REPORT:

The patient was a 63-year-old female. Mastectomy had been performed for breast cancer (pStage IIB) 15 years earlier at another hospital. Metastasis to the lumbar spine had been detected 4 years prior to referral to us and the patient had undergone hormonal therapy with an aromatase inhibitor. Furthermore, early primary sigmoid colon cancer had been endoscopically resected 2 years before referral. The patient was diagnosed with cancer recurrence in the colon at follow-up examinations performed 2 years after that endoscopic resection. After referral to our hospital, laparoscopic sigmoidectomy was performed. Based on the histopathological examination and immunohistological staining results (positive for cytokeratin 7, GATA-binding protein 3, estrogen receptor and human epidermal growth factor receptor-related 2 (2+); negative for cytokeratin 20, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15 and caudal-related homeobox 2) the final pathological diagnosis was CMBC.

CONCLUSION:

Although extremely rare, the possibility of CMBC should be considered in the case of colonic tumors in patients with a history of breast cancer.

• Authors: Hiroyuki Inoue, Tomohiro Arita, Yoshiaki Kuriu, Hiroki Shimizu, Jun Kiuchi, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
• Journal: In vivo (Athens, Greece) (In Vivo) 2022 Jan-Feb Vol. 36 Issue 1 Pg. 522-527 ISSN: 1791-7549 [Electronic] Greece
• PMID: 34972757 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Topics

• Breast Neoplasms (surgery)
• Colon, Sigmoid
• Female
• Humans
• Mastectomy
• Middle Aged
• Neoplasm Recurrence, Local
• Sigmoid Neoplasms (surgery)