Role of arachidonic acid lipoxygenase pathway in Asthma.

Abstract

The arachidonic acid (AA) metabolism pathways play a key role in immunological response and inflammation diseases, such as asthma, etc. AA in cell membranes can be metabolized by lipoxygenases (LOXs) to a screen of bioactive substances that include leukotrienes (LTs), lipoxins (LXs), and eicosatetraenoic acids (ETEs), which are considered closely related to the pathophysiology of respiratory allergic disease. Studies also verified that drugs regulating AA LOXs pathway have better rehabilitative intervention for asthma. This review aims to summarize the physiological and pathophysiological importance of AA LOXs metabolism pathways in asthma and to discuss its prospects of therapeutic strategies.

• Authors: Yacan Luo, Minli Jin, Lejing Lou, Song Yang, Chengye Li, Xi Li, Meixi Zhou, Chang Cai
• Journal: Prostaglandins & other lipid mediators (Prostaglandins Other Lipid Mediat) Vol. 158 Pg. 106609 (02 2022) ISSN: 1098-8823 [Print] United States
• PMID: 34954219 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Leukotrienes
• Lipoxins
• Arachidonate Lipoxygenases
• Lipoxygenases
• Arachidonate 5-Lipoxygenase

Topics

• Arachidonate 5-Lipoxygenase
• Arachidonate Lipoxygenases
• Asthma (drug therapy)
• Humans
• Leukotrienes
• Lipoxins
• Lipoxygenases