Abstract |
Breast cancer is one of the most common cancers in the world with tumor heterogeneity. Currently, cancer treatment mainly relies on surgical intervention, chemotherapy, and radiotherapy, for which the side effects, drug resistance and cost need to be resolved. In this study, we develop a natural medicine targeted therapy system. Phosphatidylcholine (PC), doxorubicin (DOX), procyanidin (PA), and epigallocatechin gallate (EGCG) are assembled and PC@DOX-PA/EGCG nanoparticles (NPs) are obtained. In addition, the HER2, ER and PR ligands were grafted on the surface of the NPs to acquire the targeted nanoparticles NP-ER, NP-ER-HER2, and NP-ER-HER2-PR. The physicochemical properties of the nanoparticles were detected and it was found that the nanoparticles are spherical and less than 200 nm in diameter. Furthermore, in vitro and in vivo results indicate that the nanoparticles can target BT-474, MCF-7, EMT-6, and MDA-MB-231 breast cancer cells, effectively inhibiting the growth of the breast cancer cells. In short, this research will provide some strategies for the treatment of heterogeneous breast cancer.
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Authors | Xiaozhen Wang, Jiecheng He, Siyuan Jiang, Yifei Gao, Ling-Kun Zhang, Liang Yin, Rong You, Yan-Qing Guan |
Journal | Journal of materials chemistry. B
(J Mater Chem B)
Vol. 10
Issue 3
Pg. 418-429
(01 19 2022)
ISSN: 2050-7518 [Electronic] England |
PMID | 34940773
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Biflavonoids
- Drug Carriers
- Ligands
- Micelles
- Phosphatidylcholines
- Proanthocyanidins
- procyanidin
- Doxorubicin
- Catechin
- epigallocatechin gallate
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Topics |
- Animals
- Antineoplastic Agents
(chemistry, therapeutic use)
- Apoptosis
(drug effects)
- Biflavonoids
(chemistry)
- Breast Neoplasms
(drug therapy)
- Catechin
(analogs & derivatives, chemistry)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Doxorubicin
(chemistry, therapeutic use)
- Drug Carriers
(chemical synthesis, chemistry)
- Drug Liberation
- Humans
- Ligands
- Mice, Inbred BALB C
- Micelles
- Phosphatidylcholines
(chemistry)
- Proanthocyanidins
(chemistry)
- Mice
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