Cancer is one of the most important public health problems in the world. The curative effect of traditional surgery,
radiotherapy and
chemotherapy is limited and has inevitable side effects. As a potential target for
tumor therapy, few studies have comprehensively analyzed the role of CALR in
cancers. Therefore, by using GeneCards, UALCAN, GEPIA, Kaplan-Meier Plotter, COSMIC, Regulome Explorer, String, GeneMANIA and TIMER databases, we collected and analyzed relevant data to conduct in-depth bioinformatics research on the CALR expression in Pan-
cancer to assess the possibility of CALR as a potential therapeutic target and survival
biomarker. We studied the CALR expression in normal human tissues and various
tumors of different stages, and found that CALR expression was associated with relapse free survival (RFS). We verified the expression of CALR in
breast cancer cell lines by vitro experiments. Mutations of CALR were widely present in
tumors. CALR interacted with different genes and various
proteins. In
tumors, a variety of immune cells are closely related to CALR. In conclusion, CALR can be used as a
biomarker for predicting prognosis and a potential target for
tumor molecular and
immunotherapy.