Abstract | PURPOSE: METHODS: Survival analysis using LDLR and HMGCR expression in the ovarian cancer patients using the dataset of Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) was carried out online. A retrospective study was performed on 65 patients who had undergone surgery for ovarian cancer. In addition, patients were divided into 2 groups: platinum resistance group and platinum sensitivity group. Serum lipid metabolism data were collected and analyzed. Protein expressions of LDLR and HMGCR in ovarian cancer tissue were detected by immunohistochemistry. RESULTS: Online survival analysis showed that patients with higher LDLR expression had poorer prognosis than those with lower LDLR expression in ovarian cancer cells, while a higher HMGCR expression was associated with better OC prognosis. Overall survival (OS) and disease-free survival (DFS) were lower in patients with higher LDLR levels (OS: P=0.046, DFS: P=0.009). Platinum-resistant patients had higher levels of low-density lipoprotein ( LDL) and cholesterol in serum as compared with platinum-sensitive patients (P<0.001). Immunohistochemistry showed that LDLR expression was high and HMGCR was low in platinum-resistant patients. CONCLUSION:
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Authors | Xueyao Huang, Xuan Wei, Sijing Qiao, Xue Zhang, Rui Li, Shunxue Hu, Hongluan Mao, Peishu Liu |
Journal | Cancer management and research
(Cancer Manag Res)
Vol. 13
Pg. 9015-9024
( 2021)
ISSN: 1179-1322 [Print] New Zealand |
PMID | 34908877
(Publication Type: Journal Article)
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Copyright | © 2021 Huang et al. |