Interactions between NLRP3 inflammasome and glycolysis in macrophages: New insights into chronic inflammation pathogenesis.

Abstract

NLRP3 inflammasome activation in macrophages fuels sterile inflammation, which has been tied with metabolic reprogramming characterized by high glycolysis and low oxidative phosphorylation. The key enzymes in glycolysis and glycolysis-related products can regulate and activate NLRP3 inflammasome. In turn, NLRP3 inflammasome is considered to affect glycolysis, as well. However, the exact mechanism remains ambiguous. On the basis of these findings, the focus of this review is mainly on the developments in our understanding of interaction between NLRP3 inflammasome activation and glycolysis in macrophages, and small molecule compounds that influence the activation of NLRP3 inflammasomes by regulating glycolysis in macrophages. The application of this interaction in the treatment of diseases is also discussed. This paper may yield valuable clues for development of novel therapeutic agent for NLRP3 inflammasome-related diseases.

• Authors: Qun Yu, Maojuan Guo, Wenyun Zeng, Miao Zeng, Xiaolu Zhang, Yue Zhang, Wenlan Zhang, Xijuan Jiang, Bin Yu
• Journal: Immunity, inflammation and disease (Immun Inflamm Dis) Vol. 10 Issue 3 Pg. e581 (03 2022) ISSN: 2050-4527 [Electronic] England
• PMID: 34904398 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

Chemical References

• Inflammasomes
• NLR Family, Pyrin Domain-Containing 3 Protein

Topics

• Glycolysis
• Humans
• Inflammasomes (metabolism)
• Inflammation (metabolism)
• Macrophages (metabolism)
• NLR Family, Pyrin Domain-Containing 3 Protein (metabolism)