A TP53-associated immune prognostic signature for the prediction of the overall survival and therapeutic responses in pancreatic cancer.

Abstract	Pancreatic cancer (PC) is a highly fatal disease correlated with an inferior prognosis. The tumor protein p53 (TP53) is one of the frequent mutant genes in PC and has been implicated in prognosis. We collected somatic mutation data, RNA sequencing data, and clinical information of PC samples in the Cancer Genome Atlas (TCGA) database. TP53 mutation was an independent prognostic predictor of PC patients. According to TP53 status, Gene set enrichment analysis (GSEA) suggested that TP53 mutations were related to the immunophenotype of pancreatic cancer. We identified 102 differentially expressed immune genes (DEIGs) based on TP53 mutation status and developed a TP53-associated immune prognostic model (TIPM), including Epiregulin (EREG) and Prolactin receptor (PRLR). TIPM identified the high-risk group with poor outcomes and more significant response potential to cisplatin, gemcitabine, and paclitaxel therapies. And we verified the TIPM in the International Cancer Genome Consortium (ICGC) cohort (PACA-AU) and Gene Expression Omnibus (GEO) cohort (GSE78229 and GSE28735). Finally, we developed a nomogram that reliably predicts overall survival in PC patients on the bias of TIPM and other clinicopathological factors. Our study indicates that the TIPM derived from TP53 mutation patterns might be an underlying prognostic therapeutic target. But more comprehensive researches with a large sample size is necessary to confirm the potential.
Authors	Yi Liu, Long Cheng, Xiangyang Song, Chao Li, Jiantao Zhang, Lei Wang
Journal	Mathematical biosciences and engineering : MBE (Math Biosci Eng) Vol. 19 Issue 1 Pg. 191-208 (01 2022) ISSN: 1551-0018 [Electronic] United States
PMID	34902987 (Publication Type: Journal Article)
Chemical References	TP53 protein, human Tumor Suppressor Protein p53
Topics	Humans Mutation Nomograms Pancreatic Neoplasms (drug therapy, genetics) Prognosis Tumor Suppressor Protein p53 (genetics, metabolism)

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