Abstract |
Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe- curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.
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Authors | Rui Zhang, Liang Cheng, Ziliang Dong, Linqian Hou, Shaohua Zhang, Zhouqi Meng, Oshra Betzer, Yihua Wang, Rachela Popovtzer, Zhuang Liu |
Journal | Materials horizons
(Mater Horiz)
Vol. 8
Issue 4
Pg. 1314-1322
(04 01 2021)
ISSN: 2051-6355 [Electronic] England |
PMID | 34821924
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Biological Products
- Polymers
- Reactive Oxygen Species
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Topics |
- Acute Kidney Injury
(chemically induced)
- Antioxidants
- Biological Products
- Humans
- Polymers
- Reactive Oxygen Species
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