Value of the CRP-albumin ratio in patients with resectable pancreatic cancer.

Abstract

Background : The C-reactive protein (CRP)-albumin ratio (CAR) was reported as a prognostic factor of resectable hepatocellular carcinoma. The aim of this study was to analyse the significance of CAR in resectable pancreatic cancer. Patients and Methods : 163 patients with curative resection for pancreatic cancer were enrolled in this retrospective study. Cases of non-curative resection were excluded. The CAR was calculated with the preoperative plasma CRP and albumin values, with a cut-off value of 0.06, as calculated in a previous report. Results : Patients in the low CAR group had significantly better overall survival (OS) and disease-free survival (DFS) compared with the high CAR group (P < 0.05). On multivariate analysis, for high CAR, CA19-9 > 300 U / ml and receipt of adjuvant chemotherapy were independent risk factors for OS and DFS. High CAR was significantly associated with advanced T stage. Conclusion : The CAR might be a prognostic factor for patients with resectable pancreatic cancer. J. Med. Invest. 68 : 244-248, August, 2021.

• Authors: Yusuke Arakawa, Katsuki Miyazaki, Masato Yoshikawa, Shinichiro Yamada, Yu Saito, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Mitsuo Shimada
• Journal: The journal of medical investigation : JMI (J Med Invest) Vol. 68 Issue 3.4 Pg. 244-255 ( 2021) ISSN: 1349-6867 [Electronic] Japan
• PMID: 34759138 (Publication Type: Journal Article)

Chemical References

• Albumins
• C-Reactive Protein

Topics

• Albumins
• C-Reactive Protein (analysis)
• Humans
• Pancreatic Neoplasms (surgery)
• Prognosis
• Retrospective Studies