Prognostic value of neutrophil-to-lymphocyte ratio in cirrhosis patients undergoing transjugular intrahepatic portosystemic shunt.

Abstract

BACKGROUND AND AIMS:

The neutrophil-to-lymphocyte-ratio (NLR) is used as an inflammatory index and has proven to be an accurate prognostic indicator for decompensated cirrhotics; however, its role in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) has not been evaluated. We examined whether NLR is associated with mortality in decompensated cirrhosis patients undergoing TIPS.

METHODS:

We performed a retrospective review of 268 decompensated cirrhotics who underwent TIPS from January 2011 to December 2015 at an academic medical center. NLR, patient demographics, manifestations of cirrhosis, TIPS indications and mortality were recorded. Univariate and multivariate Cox regression analyses for prognostic factors associated with 30-day and 90-day post TIPS mortality were performed.

RESULTS:

A total of 129 (48%) patients received TIPS for refractory ascites with 79 (29%) for variceal bleeding, 14 (5%) for hepatic hydrothorax, and 46 (17%) for other indications. Cirrhosis etiology included hepatitis C (36%), alcohol (28%), nonalcoholic steatohepatitis (20%), or other (15%). Median NLR was 4.42 (IQR 2.75-7.19). Univariate and multivariate analysis showed NLR as an independent predictive factor of 30-day and 90-day mortality. Furthermore, in patients with a Model of End-Stage Liver Disease (MELD) ≤ 15, NLR is superior to MELD/MELD-Na score in predicting 30-day and 90-day mortality. In patients with MELD > 15, MELD/MELD-Na score is superior to NLR.

CONCLUSION:

Our data indicate that elevated NLR independently predicts 30-day and 90-day mortality. In patients with a MELD ≤ 15, NLR is a better prognostic factor than MELD or MELD-Na in predicting short-term mortality.

• Authors: Wei Zhang, Mahmoud Aryan, Zhiguo Chen, Walid Khan, Blake Thompson, Elizabeth Kwenda, Brian Geller, Giuseppe Morelli
• Journal: European journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 34 Issue 4 Pg. 435-442 (04 01 2022) ISSN: 1473-5687 [Electronic] England
• PMID: 34750323 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Sodium

Topics

• End Stage Liver Disease (complications)
• Esophageal and Gastric Varices (complications, surgery)
• Gastrointestinal Hemorrhage (complications)
• Humans
• Liver Cirrhosis (complications)
• Lymphocytes
• Neutrophils
• Portasystemic Shunt, Transjugular Intrahepatic (adverse effects)
• Prognosis
• Retrospective Studies
• Sodium
• Treatment Outcome