Lipopolysaccharides derived from gram-negative bacterial pool of human gut microbiota promote inflammation and obesity development.

Abstract

Lipopolysaccharide (LPS) is the major component of the outer membrane of Gram-negative bacteria. It is found from intestinal microbes in the circulatory system and considered a trigger factor for low-grade inflammation in obesity. High-fat diet intake and its related obesity can cause gut microbiota disorder, leading to increased gut permeability, paracellular absorption and transcellular transport of endogenous endotoxin in the cardiovascular system. High-fat diet intake can also increase plasma LPS levels, and causing chronic or "low-grade" inflammation. In this review article, we summarize the recent research advancements on the mechanism of low-grade inflammation and its related obesity. We also propose several approaches that can be used to reduce endogenous endotoxin absorption.Supplemental data for this article is available online at https://doi.org/10.1080/08830185.2021.1996573 .

• Authors: Liyu Du, Xi Lei, Jie Wang, Li Wang, Qingping Zhong, Xiang Fang, Pan Li, Bing Du, Yutao Wang, Zhenlin Liao
• Journal: International reviews of immunology (Int Rev Immunol) Vol. 41 Issue 1 Pg. 45-56 ( 2022) ISSN: 1563-5244 [Electronic] England
• PMID: 34726960 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Endotoxins
• Lipopolysaccharides

Topics

• Endotoxins
• Gastrointestinal Microbiome
• Gram-Negative Bacteria
• Humans
• Inflammation
• Lipopolysaccharides
• Obesity (complications)