Abstract | OBJECTIVE: METHODS: RESULTS: Serum E2 levels in POF model mice were decreased, whereas FSH and LH levels were dramatically increased. Serum levels of LH and FSH were reduced in POF model mice treated with EXD (moderate and high doses) and premarin, while serum level of E2 were increased after POF model mice had been treated with EXD and premarin. The CD3+ T, CD4+ T, CD4+ T/CD8+ T ratio of mice in the positive control group and high and medium dose groups of EXD increased (P < 0.05), and the number of CD8 + T cells decreased significantly (P < 0.05) when compared with the model group. Bone morphogenetic protein 15 (BMP15) and Akt were repressed in autoimmune POF model mice, whereas high expression was observed in control mice and those treated with EXD (moderate and high doses) and premarin. CONCLUSION:
EXD is effective in treating ZP3-induced POF in mice and increased expression of BMP-15, and Akt is represented in the mechanism accounting for this therapeutic effect.
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Authors | Xiao-Li Zhang, Jing Li, Xiao-Lin Zhou, Qiao-Li Chen |
Journal | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
(J Tradit Chin Med)
Vol. 41
Issue 5
Pg. 725-731
(10 2021)
ISSN: 2589-451X [Electronic] China |
PMID | 34708630
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- er-xian decoction
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Animals
- Drugs, Chinese Herbal
(therapeutic use)
- Female
- Follicle Stimulating Hormone
- Luteinizing Hormone
- Mice
- Primary Ovarian Insufficiency
(drug therapy, genetics, metabolism)
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