Role of PRKDC in cancer initiation, progression, and treatment.

Abstract

The PRKDC gene encodes the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein. DNA-PKcs plays an important role in nonhomologous end joining (NHEJ) of DNA double-strand breaks (DSBs) and is also closely related to the establishment of central immune tolerance and the maintenance of chromosome stability. The occurrence and development of different types of tumors and the results of their treatment are also influenced by DNA-PKcs, and it may also predict the results of radiotherapy, chemotherapy, and therapy with immune checkpoint inhibitors (ICIs). Here, we discuss and review the structure and mechanism of action of PRKDC and DNA-PKcs and their relationship with cancer.

• Authors: Yu Chen, Yi Li, Jiani Xiong, Bin Lan, Xuefeng Wang, Jun Liu, Jing Lin, Zhaodong Fei, Xiaobin Zheng, Chuanben Chen
• Journal: Cancer cell international (Cancer Cell Int) Vol. 21 Issue 1 Pg. 563 (Oct 26 2021) ISSN: 1475-2867 [Print] England
• PMID: 34702253 (Publication Type: Journal Article, Review)
• Copyright: © 2021. The Author(s).