Abstract | RATIONALE: OBJECTIVES: METHODS: Male Sprague-Dawley rats were given morphine at escalating doses before treatment was discontinued to induce a spontaneous morphine withdrawal. Then, vehicle or mitragynine (5 mg/kg, 15 mg/kg, or 30 mg/kg) substitution was given for 3 days. A vehicle-treated group was used as a control. Withdrawal signs were scored after 24 h, 48 h, and 72 h, while novel object recognition (NOR) and attentional set-shifting (ASST) were tested during the substitution period. RESULTS: Discontinuation of morphine significantly induced morphine withdrawal signs and cognitive deficit in the ASST. The substitution with mitragynine was able to alleviate the withdrawal signs. Mitragynine did not affect the recognition memory in the NOR but significantly improved the reversal learning deficit in the morphine-withdrawn rats. CONCLUSIONS:
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Authors | Chiek Yi You, Zurina Hassan, Christian P Müller, Farah Wahida Suhaimi |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 239
Issue 1
Pg. 313-325
(Jan 2022)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 34693456
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Chemical References |
- Secologanin Tryptamine Alkaloids
- Morphine
- mitragynine
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Topics |
- Animals
- Cognition
- Male
- Mitragyna
- Morphine
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Secologanin Tryptamine Alkaloids
(pharmacology)
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