Abstract | BACKGROUND: CASE PRESENTATION: This case describes a patient with a history significant for hyperlipidemia who was diagnosed with relapsed acute myeloid leukemia. After four doses of gilteritinib monotherapy, she abruptly developed acute systolic heart failure with global hypokinesis and septal wall motion abnormalities. Two days after discontinuation, cardiac magnetic resonance imaging showed partial recovery of her left ventricular ejection fraction as well as myocardial edema and non-ischemic fibrosis suggestive of inflammatory cardiomyopathy. She underwent intravenous diuresis and eventually started guideline-directed heart failure therapy. Follow-up cardiac magnetic resonance imaging five months later showed improved ejection fraction with mild non-ischemic fibrosis and resolution of myocardial edema and inflammation. She later received an allogeneic stem cell transplant from a matched unrelated donor. CONCLUSIONS:
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Authors | Lisa Kim, Brian Fowler, Courtney M Campbell, Jeremy Slivnick, Haseeb Nawaz, Yaquta Kaka, Patrick Ruz, Ajay Vallakati, Ragavendra Baliga, Sumithira Vasu, Daniel Addison |
Journal | Cardio-oncology (London, England)
(Cardiooncology)
Vol. 7
Issue 1
Pg. 36
(Oct 22 2021)
ISSN: 2057-3804 [Electronic] England |
PMID | 34686212
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s). |