Receptors and ligands for herpes simplex viruses: Novel insights for drug targeting.

Abstract

Human herpes simplex viruses (HSVs) belong to the Herpesviridae family. At present, no vaccine or curative treatment is available for the prevention of HSV infections. Here, we review the cell surface receptors that are recognized by HSV's glycoprotein B, glycoprotein C, glycoprotein D, and the glycoprotein H - glycoprotein L complex to facilitate entry into host cells. These receptors include heparan sulfate (HS), herpesvirus entry mediator (HVEM), and nectin-1/-2, 3-O-sulfated heparan sulfate (3-OS HS).

• Authors: Yiwei Huang, Yuyun Song, Jichen Li, Changning Lv, Zhe-Sheng Chen, Zhijun Liu
• Journal: Drug discovery today (Drug Discov Today) Vol. 27 Issue 1 Pg. 185-195 (01 2022) ISSN: 1878-5832 [Electronic] England
• PMID: 34678489 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2021 Elsevier Ltd. All rights reserved.

Chemical References

• Antiviral Agents
• Ligands
• Membrane Glycoproteins
• Viral Envelope Proteins

Topics

• Antiviral Agents (pharmacology)
• Drug Development
• Drug Discovery (methods)
• Herpes Simplex (drug therapy, prevention & control, virology)
• Herpesvirus 1, Human (drug effects, physiology)
• Humans
• Ligands
• Membrane Glycoproteins (classification)
• Viral Envelope Proteins (classification, physiology)
• Virus Internalization (drug effects)