Risk factors for mortality in patients undergoing continuous renal replacement therapy after cardiac surgery.

Abstract

BACKGROUND:

To investigate the risk factors for mortality in patients with acute kidney injury requiring continuous renal replacement therapy (AKI-CRRT) after cardiac surgery.

METHODS:

In this retrospective study, patients who underwent AKI-CRRT after cardiac surgery in our centre from January 2015 to January 2020 were included. Univariable and multivariable analyses were performed to identify the risk factors for in-hospital mortality.

RESULTS:

A total of 412 patients were included in our study. Of these, 174 died after AKI-CRRT, and the remaining 238 were included in the survival control group. Multivariable logistic regression analysis revealed that EuroSCORE > 7 (odds ratio [OR], 3.72; 95% confidence interval [CI], 1.92-7.24; p < 0.01), intraoperative bleeding > 1 L (OR, 2.14; 95% CI, 1.19-3.86; p = 0.01) and mechanical ventilation time > 70 h (OR, 5.03; 95% CI, 2.40-10.54; p < 0.01) were independent risk factors for in-hospital mortality in patients who had undergone AKI-CRRT. Our study also found that the use of furosemide after surgery was a protective factor for such patients (odds ratio, 0.48; 95% confidence interval, 0.25-0.92; p = 0.03).

CONCLUSIONS:

In summary, the mortality of patients with AKI-CRRT after cardiac surgery remains high. The EuroSCORE, intraoperative bleeding and mechanical ventilation time were independent risk factors for in-hospital mortality. Continuous application of furosemide may be associated with a better outcome.

• Authors: Chang Liu, Hai-Tao Zhang, Li-Jun Yue, Ze-Shi Li, Ke Pan, Zhong Chen, Su-Ping Gu, Tuo Pan, Jun Pan, Dong-Jin Wang
• Journal: BMC cardiovascular disorders (BMC Cardiovasc Disord) Vol. 21 Issue 1 Pg. 509 (10 21 2021) ISSN: 1471-2261 [Electronic] England
• PMID: 34674651 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021. The Author(s).

Topics

• Acute Kidney Injury (etiology, mortality, therapy)
• Age Factors
• Aged
• Cardiac Surgical Procedures (adverse effects)
• Continuous Renal Replacement Therapy
• Female
• Hospital Mortality
• Humans
• Intraoperative Complications
• Male
• Middle Aged
• Multivariate Analysis
• Postoperative Complications (mortality, therapy)
• Regression Analysis
• Respiration, Artificial
• Retrospective Studies
• Risk Factors