Management of Urological Malignancy in Heart and Lung Transplant Recipients: An Irish National Cohort Study.

Abstract

OBJECTIVES:

Following the first hearttransplantin Ireland in 1985, there have been almost 700 deceased donor heart and lung transplants carried out in Ireland at a single institution. In this retrospective study, our aim was to assess the incidence and management of urological malignancies arising in this national cohort.

MATERIALS AND METHODS:

Our retrospective analysis included all heart and lung transplant recipients identified as having a urological malignancy. Primary outcome variables included incidence, management, and clinical outcomes following cancer diagnosis.

RESULTS:

A total of 28 patients (4.1%) had radiologically or histologically confirmed urological malignancies. Fourteen patientswere diagnosedwith prostate cancer, with 13 who underwent radical treatment. Eight renal cell carcinomas were diagnosed in heart transplant recipients, with 5 who underwent nephrectomies. Two bladder cancers and 1 uppertract urothelial carcinoma were diagnosed and managed with endoscopic resection, radiotherapy, and nephroureterectomy, respectively. Two patients were diagnosed with penile squamous cell carcinoma and managed with radical surgery and lymph node dissection/sampling, with 1 patient receiving adjuvant chemoradiotherapy.

CONCLUSIONS:

Urological malignancies are not common in heart and lung transplant recipients; however, standard management options can be safely used, including radical surgery. Prospective monitoring of these patients and potential considerations for screening should be maintained.

• Authors: Robert A Keenan, Usman Haroon, Paul Ryan, Bronagh Harrington, Andrew Jones, Mohammed Aboelmagd, Stephen Connolly, Kiaran J O'Mally, David Galvin, Nicholas Hegarty
• Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation (Exp Clin Transplant) Vol. 19 Issue 10 Pg. 1069-1075 (10 2021) ISSN: 2146-8427 [Electronic] Turkey
• PMID: 34641776 (Publication Type: Journal Article)

Topics

• Carcinoma, Transitional Cell (etiology)
• Cohort Studies
• Female
• Heart Transplantation (adverse effects)
• Humans
• Incidence
• Kidney Transplantation (adverse effects)
• Lung
• Male
• Prospective Studies
• Retrospective Studies
• Risk Factors
• Tissue Donors
• Transplant Recipients
• Treatment Outcome
• Urinary Bladder Neoplasms (etiology)
• Urologic Neoplasms (diagnosis, epidemiology, surgery)