Abstract | BACKGROUND: METHODS: The study enrolled 500 consecutive patients with primary HCC who underwent curative and primary hepatectomy. Patient characteristics and prognoses were evaluated according to histologic liver inflammation assessed by the New Inuyama Classification. RESULTS: Severe liver inflammation (A3) was observed in 97 patients (19.4%) and nonsevere liver inflammation (A0-2) in 403 patients (80.6%). The patients with A3 had a significantly poorer prognosis than those with A0-2 in terms of relapse-free survival (p < 0.0001, log-rank) and overall survival (p = 0.0013, log-rank). The study showed that A3 is an independent poor prognostic factor (hazard ratio, 1.36; 95% confidence interval [Cl], 1.02-1.81; p = 0.039), and that Child-Pugh grade B and multiple tumors are associated with relapse-free survival. Furthermore, The significant predictors of early recurrence (within 2 years after hepatectomy) were A3 (odds ratio, 2.10; 95% CI, 1.25-3.55; p = 0.005), a des-γ-carboxyprothrombin level higher than 40 mAU/mL, and multiple tumors. CONCLUSIONS:
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Authors | Tatsunori Miyata, Hiromitsu Hayashi, Yo-Ichi Yamashita, Kazuki Matsumura, Takaaki Higashi, Katsunori Imai, Hidetoshi Nitta, Akira Chikamoto, Toru Beppu, Hideo Baba |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 29
Issue 2
Pg. 893-902
(Feb 2022)
ISSN: 1534-4681 [Electronic] United States |
PMID | 34595665
(Publication Type: Journal Article)
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Copyright | © 2021. Society of Surgical Oncology. |
Topics |
- Carcinoma, Hepatocellular
(surgery)
- Hepatectomy
(adverse effects)
- Humans
- Inflammation
(etiology)
- Liver Neoplasms
(surgery)
- Neoplasm Recurrence, Local
- Prognosis
- Retrospective Studies
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