Atherogenic Index of Plasma and the Risk of In-Stent Restenosis in Patients with Acute Coronary Syndrome beyond the Traditional Risk Factors.

Abstract

AIM:

Recently, the atherogenic index of plasma (AIP) has been proposed as a novel, reliable plasma atherogenicity marker. This study aimed to investigate the association of AIP with the risk of in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS).

METHODS:

This study retrospectively enrolled patients with ACS followed by angiography within 6 to 18 months after successful percutaneous coronary intervention (PCI) with a drug-eluting stent (DES). And the participants were divided into ISR or non-ISR groups based on the angiographic follow-up results. AIP was defined as the base 10 logarithm of the ratio of serum triglyceride (mmol/L) to high-density lipoprotein cholesterol (mmol/L).

RESULTS:

This study recruited 1319 patients with ACS, 199 of which had ISR. Compared with the non-ISR group, patients in the ISR group had higher level of AIP (0.199±0.290 vs 0.131±0.282, p=0.002). In the multiple logistic regression analysis, AIP was an independent risk factor for DES-ISR (OR=2.100, 95% CI 1.134 to 3.891, p=0.018). When we modulated AIP as a categorical variable, the risk of DES-ISR increased in quartile 4 compared to quartile 1 (OR=1.713, 95% CI 1.040 to 2.822, p=0.034). Furthermore, this association remains stable in various subgroups. Unexpectedly, the subgroup analysis suggested AIP and DES-ISR had a stronger positive association in individuals with low-density lipoprotein cholesterol (LDL-C) ＜1.8 mmol/L.

CONCLUSIONS:

AIP and the risk of DES-ISR were positively and independently correlated in patients with ACS, especially in those with an LDL-C ＜1.8 mmol/L.

• Authors: Yong Zhu, Maolin Chen, Kesen Liu, Ang Gao, Xiangyun Kong, Yan Liu, Hongya Han, Hong Li, Huagang Zhu, Jianwei Zhang, Yingxin Zhao
• Journal: Journal of atherosclerosis and thrombosis (J Atheroscler Thromb) Vol. 29 Issue 8 Pg. 1226-1235 (Aug 01 2022) ISSN: 1880-3873 [Electronic] Japan
• PMID: 34497172 (Publication Type: Journal Article)

Chemical References

• Cholesterol, LDL

Topics

• Acute Coronary Syndrome (complications, etiology)
• Cholesterol, LDL
• Coronary Angiography
• Coronary Restenosis (diagnosis, etiology)
• Drug-Eluting Stents (adverse effects)
• Humans
• Percutaneous Coronary Intervention
• Retrospective Studies
• Risk Factors
• Treatment Outcome