Both subventricular zone (SVZ) contact and
isocitrate dehydrogenase 1 (IDH1) mutation have been reported to be related to the outcome of
glioma, respectively. However, far too little attention has been paid to the role of
tumor edge-SVZ distance in the outcome of
glioma. We aim to assess the value of
tumor-SVZ distance, as well as combined
tumor-SVZ distance and IDH status, in predicting the outcome of
gliomas (WHO grade II-IV). Here, the MR images and clinical data from 146 patients were included in the current study. The relationship between survival and the
tumor-SVZ distance as well as survival and combination of
tumor-SVZ distance and IDH status were determined via univariate and multivariate analyses. In univariate analysis of
tumor-SVZ distance, the patients were divided into three types (SVZ involvement,
tumor-SVZ distance from 0 to 10 mm, and
tumor-SVZ distance >10 mm). The results showed that the OS (p = 0.02) and PFS (p = 0.002) for the patients had a positive correlation with the
tumor-SVZ distance. In addition, simple linear correlation found a significant relationship between the two parameters (OS and PFS) and
tumor-SVZ distance in patients with non-SVZ-contacting
glioma. Combination analysis of the
tumor-SVZ distance and IDH status showed that IDH1 mutation and SVZ non-involvement enable favorable outcomes, whereas IDH1 wild type with SVZ involvement indicates a significantly worse prognosis in all patients. Moreover, in patients with non-SVZ-contacting
glioma, IDH1 mutation concurrent with
tumor-SVZ distance >10 mm has better OS and PFS. IDH1 wild type and
tumor-SVZ distance from 0 to 10 mm suggest poorer OS and PFS. Multivariate analysis showed WHO grade IV, SVZ involvement,
tumor-SVZ distance from 0 to 10 mm, IDH1 mutation, gross total resection, and
chemotherapy serve as independent predictors of OS. WHO grade IV, SVZ involvement,
tumor-SVZ distance from 0 to 10 mm, IDH1 mutation, and
chemotherapy serve as independent predictors of PFS of patients with
glioma. In conclusion,
tumor-SVZ distance and IDH1 mutation status are the determinants affecting patient outcome.