Paraneoplastic autoimmune and inflammatory disorders are often associated with
myelodysplastic syndromes (MDS). The etiopathogenesis of MDS-associated autoimmune and inflammatory disorders is still unclear and treatment options are limited. Patients with MDS are at high risk of
infections, which can be increased by the use of
steroids. In the present study, we report on two patients with MDS-related autoimmune and inflammatory disorders who were in remission and reduced the
steroid dose with
5-azacytidine treatment. The first case was a 67-year-old patient diagnosed with MDS and the whole-body
erythroderma was the chief complaint. When the patient was treated with
decitabine,
steroid treatment was needed to control the
erythroderma. When we changed
decitabine to
5-azacytidine, both his
erythroderma and his dependency on the
steroid treatment were resolved. The second patient was a 68-year-old man with MDS who presented with
Sweet's syndrome.
Sweet's syndrome was completely treated after the first cycle of
5-azacytidine. In addition,
Sweet's syndrome can occur as an adverse reaction of 5-azacitidine, so we illustrate that it is important to distinguish whether
Sweet's syndrome is MDS-related skin disorders or 5-azacitidine-related skin side-effects.