Salidroside attenuates cardiac dysfunction in a rat model of diabetes.

Abstract

AIM:

This study aimed to investigate the therapeutic effects of salidroside on diabetes-induced cardiovascular disease.

METHODS:

Sprague-Dawley rats treated with 65 mg/kg of streptozotocin (STZ) on a daily basis were used to establish the diabetic rat model (blood glucose levels >13.9 mmol/L). Cardiac functions of diabetic rats were evaluated by their haemodynamic alterations. Western blot assay was performed to evaluate the protein levels of multiple signalling pathway factors. Quantitative real-time PCR assay was performed to investigate the inflammation and oxidative stress of diabetic rats.

RESULTS:

Salidroside treatment improved the cardiac functions of diabetic rats. In addition, salidroside therapy attenuated the cardiac oxidative stress induced by diabetes. Salidroside inhibited the diabetes-induced inflammation in diabetic rat hearts. The apoptosis of cardiomyocytes was also alleviated by the treatment of salidroside. Salidroside also upregulated the phosphorylation levels of AMPK, ACC, TSC2 and RAPTOR.

CONCLUSION:

Salidroside exerts protective effects against diabetes-induced cardiac dysfunction by modulating the mTOR and AMPK signalling pathways.

• Authors: Weiwei Hao, Na Li, Caifeng Mi, Qiang Wang, Yuanyuan Yu
• Journal: Diabetic medicine : a journal of the British Diabetic Association (Diabet Med) Vol. 39 Issue 3 Pg. e14683 (03 2022) ISSN: 1464-5491 [Electronic] England
• PMID: 34467560 (Publication Type: Journal Article)
• Copyright: © 2021 Diabetes UK.

Chemical References

• Glucosides
• Phenols
• Streptozocin
• TOR Serine-Threonine Kinases
• AMP-Activated Protein Kinases
• rhodioloside

Topics

• AMP-Activated Protein Kinases (metabolism)
• Animals
• Apoptosis (drug effects)
• Diabetic Cardiomyopathies (metabolism)
• Disease Models, Animal
• Glucosides (administration & dosage, pharmacology)
• Inflammation (drug therapy)
• Male
• Myocytes, Cardiac (cytology, drug effects)
• Oxidative Stress (drug effects)
• Phenols (administration & dosage, pharmacology)
• Rats
• Rats, Sprague-Dawley
• Signal Transduction (drug effects)
• Streptozocin (toxicity)
• TOR Serine-Threonine Kinases (metabolism)