Abstract |
Ten secondary metabolites, including a new grifolin analog, grifolin B (1); a new homovalencic acid derivative, 12-hydroxyhomovalencic acid (7); and a compound isolated from a natural source for the first time (9), along with seven known compounds, grifolin (2), averantin (3), 7-chloroaverantin (4), 1'-O-methylaverantin (5), 7-hydroxy-2-(2-hydroxypropyl)-5-pentylchromone (6), homovalencic acid (8), and bekeleylactone E (10), were isolated from two fungal strains. The structures of 1-10 were identified by detailed analysis and comparison of their spectroscopic data with literature values. Compounds 9 and 10 showed moderate cytotoxic activity against a panel of cancer cell lines (PC-3, HCT-15, MDA-MB-231, ACHN, NCI-H23, NUGC-3), with the GI50 values ranging from 1.1 µM to 3.6 µM, whereas 1 displayed a weak 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity without cytotoxicity against all tested cell lines.
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Authors | Cao Van Anh, Jong Soon Kang, Byeoung-Kyu Choi, Hwa-Sun Lee, Chang-Su Heo, Hee Jae Shin |
Journal | Marine drugs
(Mar Drugs)
Vol. 19
Issue 8
(Jul 26 2021)
ISSN: 1660-3397 [Electronic] Switzerland |
PMID | 34436253
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Antioxidants
- Biphenyl Compounds
- Picrates
- Polyketides
- Terpenes
- 1,1-diphenyl-2-picrylhydrazyl
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Topics |
- Antineoplastic Agents
(pharmacology)
- Antioxidants
(pharmacology)
- Aquatic Organisms
- Aspergillus
(chemistry)
- Biphenyl Compounds
- Cell Line, Tumor
- Humans
- Picrates
- Polyketides
(pharmacology)
- Structure-Activity Relationship
- Terpenes
(pharmacology)
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