[Lupus anticoagulant and ischemic strokes: about two case reports].

Abstract

Antiphospholipid syndrome (APS) is an autoimmune disease characterized by thrombotic clinical manifestations, including ischemic stroke. Testing for lupus anticoagulant (LA) among antiphospholipid antibodies is key to the diagnosis of antiphospholipid syndrome (APS). Given the impact on patient management, close clinician-pathologist collaboration is crucial for the presence of LA in a thrombotic setting. Testing for LA must be carried out using specific and appropriate clotting assays and the pathologist should be aware of interferences. We report here two cases of stroke associated with the presence of LA, and recall the strategy for screening for LA.

• Authors: Julie Hilaire, Clara Noizat, Minh-Toan Duong, Maxime Delrue, Dominique Hervé, Alain Stepanian, Marie Neuwirth, Arezki Hadj-Ali, Bérangère S Joly, Agnès Veyradier, Virginie Siguret, Nicolas Béranger
• Journal: Annales de biologie clinique (Ann Biol Clin (Paris)) Vol. 79 Issue 4 Pg. 361-367 (Aug 01 2021) ISSN: 1950-6112 [Electronic] France
• Vernacular Title: Anticoagulant lupique et accidents vasculaires cérébraux ischémiques : à propos de deux observations.
• PMID: 34427558 (Publication Type: Case Reports, Journal Article)

Chemical References

• Lupus Coagulation Inhibitor

Topics

• Antiphospholipid Syndrome (complications, diagnosis)
• Brain Ischemia (diagnosis)
• Humans
• Ischemic Stroke
• Lupus Coagulation Inhibitor
• Stroke (diagnosis)