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Comprehensive analysis of ubiquitin-proteasome system genes related to prognosis and immunosuppression in head and neck squamous cell carcinoma.

Abstract
The ubiquitin-proteasome system (UPS) with a capacity of degrading multiple intracellular proteins is an essential regulator in tumor immunosurveillance. Tumor cells that escape from recognition and destruction of immune system have been consistently characterized an important hallmark in the setting of tumor progression. Little know about the exact functions of UPS-related genes (UPSGs) and their relationships with antitumor immunity in head and neck squamous cell carcinoma (HNSCC) patients. In this study, for the first time, we comprehensively identified 114 differentially expressed UPSGs (DEUPSGs) and constructed a prognostic risk model based on the eight DEUPSGs (BRCA1, OSTM1, PCGF2, PSMD2, SOCS1, UCHL1, UHRF1, and USP54) in the TCGA-HNSCC database. This risk model was validated using multiple data sets (all P < 0.05). The high-risk score was found to be an independently prognostic factor in HNSCC patients and was significantly correlated with T cells suppression. Accordingly, our risk model can act as a prognostic signature and provide a novel concept for improving the precise immunotherapy for patients with HNSCC.
AuthorsJuncheng Wang, Jianing Li, Luan Zhang, Yuexiang Qin, Fengyu Zhang, Rulong Hu, Huihong Chen, Yongquan Tian, Zhifeng Liu, Yuxi Tian, Xin Zhang
JournalAging (Aging (Albany NY)) Vol. 13 Issue 16 Pg. 20277-20301 (08 16 2021) ISSN: 1945-4589 [Electronic] United States
PMID34398824 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Ubiquitin
  • Proteasome Endopeptidase Complex
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor
  • Female
  • Gene Expression Regulation, Neoplastic
  • Head and Neck Neoplasms (enzymology, genetics, immunology, mortality)
  • Humans
  • Immunosuppression Therapy
  • Male
  • Middle Aged
  • Prognosis
  • Proteasome Endopeptidase Complex (genetics)
  • Squamous Cell Carcinoma of Head and Neck (enzymology, genetics, immunology, mortality)
  • Ubiquitin (genetics, immunology)

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