Abstract |
Although angiogenesis-osteogenesis coupling is important in ankylosing spondylitis (AS), therapeutic agents targeting the vasculature remain elusive. Here, we identified activating transcription factor 6 (ATF6) as an important regulator of angiogenesis in the pathogenesis of AS. First, we found that ATF6 and fibroblast growth factor 2 ( FGF2) levels were higher in SKG mice and in cartilage of pateints with AS1. The proangiogenic activity of human chondrocytes was enhanced by the activation of the ATF6-FGF2 axis following 7 days of stimulation with inflammatory factors, e.g., tumor necrosis factor alpha (TNF-α), interferon-γ (IFN-γ) or interleukin-17 (IL-17). Mechanistically, ATF6 interacted with the FGF2 promotor and promoted its transcription. Treatment with the ATF6 inhibitor Ceapin-A7 inhibited angiogenesis in vitro and angiogenesis-osteogenesis coupling in vivo. ATF6 may aggravate angiogenesis-osteogenesis coupling during AS by mediating FGF2 transcription in chondrocytes, implying that ATF6 represents a promising therapeutic target for AS.
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Authors | Mengjun Ma, Hongyu Li, Peng Wang, Wen Yang, Rujia Mi, Jiahao Zhuang, Yuhang Jiang, Yixuan Lu, Xin Shen, Yanfeng Wu, Huiyong Shen |
Journal | iScience
(iScience)
Vol. 24
Issue 7
Pg. 102791
(Jul 23 2021)
ISSN: 2589-0042 [Electronic] United States |
PMID | 34296071
(Publication Type: Journal Article)
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Copyright | © 2021 The Authors. |