Association between IDH mutational status and tumor-associated epilepsy or venous thromboembolism in patients with grade II and III astrocytoma.

Abstract

In previous studies, isocitrate dehydrogenase (IDH) mutations were associated with tumor-associated epilepsy (TAE) and venous thromboembolism (VTE). We examined the relationship between IDH mutations in grade II/III astrocytomas and TAE/VTE according to the 2016 World Health Organization classification. The clinical data of patients with newly diagnosed grade II/III gliomas who were treated at Tohoku University Hospital from January 2010 to December 2018 were reviewed. Associations between TAE or VTE and the clinical/biological characteristics, histology, and IDH1/2 mutational status in patients with grade II/III gliomas were evaluated. Of the initial 137 patients (290 hospitalizations), 117 patients (203 hospitalizations) were included in the TAE group and 124 patients (213 hospitalizations) were included in the VTE group. Seventy-eight patients (66.7%) in the TAE group were diagnosed with astrocytoma and 38/78 (48.3%) presented with TAE. According to the multivariable analysis, the IDH mutational status and male sex were associated independently with an increased risk of TAE (p < 0.05). Eighty-five patients (68.5%) in the VTE group were diagnosed with astrocytoma. VTE was observed in 16/161 (9.9%) hospitalizations. According to the multivariable analysis, age, diffuse astrocytoma histology, and resection were associated independently with an increased risk of VTE. The decision tree analysis showed that TAE was more frequent in younger patients while VTE was more frequent in older patients. This study demonstrated that the IDH mutational status was associated with TAE but not with VTE. Therefore, a future large-scale study is needed to provide sufficient evidence. TAE was more common in young patients, while VTE was more common in the elderly.

• Authors: Yoshinari Osada, Ryuta Saito, Satoshi Miyata, Takuhiro Shoji, Ichiyo Shibahara, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Mika Watanabe, Teiji Tominaga
• Journal: Brain tumor pathology (Brain Tumor Pathol) Vol. 38 Issue 3 Pg. 218-227 (Jul 2021) ISSN: 1861-387X [Electronic] Japan
• PMID: 34269949 (Publication Type: Journal Article)
• Copyright: © 2021. The Japan Society of Brain Tumor Pathology.

Chemical References

• Isocitrate Dehydrogenase

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Astrocytoma (complications, genetics, pathology)
• Brain Neoplasms (complications, genetics, pathology)
• Child
• Child, Preschool
• Decision Trees
• Epilepsy (etiology, genetics)
• Female
• Genetic Association Studies
• Humans
• Isocitrate Dehydrogenase (genetics)
• Male
• Middle Aged
• Multivariate Analysis
• Mutation (genetics)
• Neoplasm Grading
• Retrospective Studies
• Risk
• Sex Factors
• Venous Thromboembolism (etiology, genetics)
• Young Adult