Methylenetetrahydrofolate Reductase Gene Polymorphism C677T is Associated with Increased Risk of Coronary Heart Disease in Chinese Type 2 Diabetic Patients.

Abstract	Objective Chronic cardiovascular diseases induced by long-term poor blood glucose control are the main cause of death in patients with type 2 diabetes mellitus (T2DM). Previous researches report that methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms might influence the occurrence of coronary heart disease (CHD) in T2DM patients. The purpose of this study was to evaluate whether MTHFR C677T and A1298C mutations are associated with the risk of CHD in T2DM patients. Methods A total of 197 subjects with T2DM were studied, of which 95 patients with CHD. The genotypes of MTHFR C677T and A1298C were analyzed by using dideoxy chain-termination method, and compared between patients with CHD and those without CHD. Results We found that the frequency of the 677T allele was significantly higher in T2DM patients with CHD than those without CHD (P=0.011). However, there was no significant difference in any of the examined haplotypes between T2DM patients with and without CHD. Furthermore, the 677T allele was associated with a higher risk of CHD development in diabetic patients with lower homocysteine (Hcy) levels (≤15 μmol/L) (P=0.006), while no effect of MTHFR gene polymorphism on the incidence of CHD was found in patients with higher Hcy levels (>15 μmol/L) (P=0.491). Conclusion The MTHFR C677T gene polymorphism is associated with the risk of CHD of diabetic patients and could be used as an effective marker for CHD in Chinese diabetic populations with normal Hcy levels.
Authors	Kun Rong Wu, Shu Fang Zhang, Zi Wan Guan, Xiao Li Li, Rui Li, Ying Yin, Yan Li
Journal	Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih (Chin Med Sci J) Vol. 36 Issue 2 Pg. 103-109 (Jun 30 2021) ISSN: 1001-9294 [Print] China
PMID	34231458 (Publication Type: Journal Article)
Chemical References	Methylenetetrahydrofolate Reductase (NADPH2)
Topics	China (epidemiology) Coronary Disease (epidemiology, genetics) Diabetes Mellitus, Type 2 (genetics) Gene Frequency Genetic Predisposition to Disease Humans Methylenetetrahydrofolate Reductase (NADPH2) (genetics) Polymorphism, Genetic Risk Factors

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