The Application of Peptides in Glioma: A Novel Tool for Therapy.

Abstract

BACKGROUND:

Glioma is the most aggressive and lethal tumor of the central nervous system. Due to the cellular heterogeneity, the invasiveness, and blood-brain barrier (BBB), current therapeutic approaches, such as chemotherapy and radiotherapy, are poorly to obtain great antitumor efficacy. However, peptides, a novel type of therapeutic agent, displayed excellent ability in the tumor, which becomes a new molecule for glioma treatment.

METHODS:

We review the current knowledge on peptides for the treatment of glioma through a PubMed-based literature search.

RESULTS:

In the treatment of glioma, peptides can be used as (i) decoration on the surface of the delivery system, facilitating the distribution and accumulation of the anti-tumor drug in target site; (ii) anti-tumor active molecules, inhibiting the growth of glioma and reducing solid tumor volume; (iii) immune-stimulating factor, and it activating immune cells in the tumor microenvironment or recruiting immune cells to the tumor for breaking out the immunosuppression by glioma cells.

CONCLUSION:

The application of peptides has revolutionized the treatment of glioma, which based on targeting, penetrating, anti-tumor activities and immunostimulatory. Moreover, better outcomes have been discovered in combining different kinds of peptides rather than a single one. Until now, more and more preclinical studies have been developed with multifarious peptides, which shows promising results in vitro or vivo with the model of glioma.

• Authors: Li Li, Jianhong Chen, Yue Ming, Bin Li, Ruoqiu Fu, Dongyu Duan, Ziwei Li, Rui Ni, Xianfeng Wang, Yueling Zhou, Lin Zhang
• Journal: Current pharmaceutical biotechnology (Curr Pharm Biotechnol) Vol. 23 Issue 5 Pg. 620-633 ( 2022) ISSN: 1873-4316 [Electronic] Netherlands
• PMID: 34182908 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Peptides

Topics

• Brain Neoplasms (drug therapy)
• Cell Line, Tumor
• Drug Delivery Systems
• Glioma (drug therapy)
• Humans
• Peptides
• Tumor Microenvironment