Abstract | INTRODUCTION: METHODS: In this cohort study, we included 168 patients (118 men, 50 women) referred to our nephrology center between February 1995 and November 2016. Mean age was 52 ± 13 years. There were 156 patients with new-onset disease and 12 patients with a relapse (n = 10) or recent use of immunosuppressive therapy (n = 2). We measured anti-PLA2R1 titer at baseline and analyzed progression to severe disease (30% increase of serum creatinine or start of immunosuppressive therapy) as a primary study endpoint over 60 months. RESULTS: There was a clear association between anti-PLA2R1 antibody titer and severity of the nephrotic syndrome. In univariate analysis, anti-PLA2R1 antibody titer was also associated with disease progression. However, in Cox proportional hazard models that included proteinuria and serum creatinine, anti-PLA2R1 antibody titer was no longer associated with clinical outcome. Results were similar when limiting the analysis to the patients with new-onset disease. CONCLUSION:
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Authors | Anne-Els van de Logt, Joana Justino, Coralien H Vink, Jan van den Brand, Hanna Debiec, Gérard Lambeau, Jack F Wetzels |
Journal | Kidney international reports
(Kidney Int Rep)
Vol. 6
Issue 6
Pg. 1677-1686
(Jun 2021)
ISSN: 2468-0249 [Electronic] United States |
PMID | 34169209
(Publication Type: Journal Article)
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Copyright | © 2021 International Society of Nephrology. Published by Elsevier Inc. |