Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study.

Abstract

OBJECTIVE:

Magnesium has been implicated in regulating blood pressure and vascular endothelial cell function, but its role in the pathophysiology of intracranial aneurysm is not known. Here we performed a Mendelian randomization analysis to investigate the association between serum magnesium concentration and risk of intracranial aneurysm.

METHODS:

Five single-nucleotide polymorphisms strongly associated with serum magnesium concentrations in a genome-wide association study in 23,829 individuals of European ancestry were used as genetic instruments. Genetic association estimates for intracranial aneurysm were obtained from a genome-wide association study in 79,429 individuals (7,495 cases and 71,934 controls). The inverse variance weighted method was used in the primary analyses to obtain the causal estimates.

RESULTS:

Higher genetically predicted serum magnesium concentrations were associated with lower risk of intracranial aneurysm. The odds ratios per 0.1 mmol/L increment in genetically predicted serum magnesium concentrations were 0.66 (95% confidence interval [CI] 0.49-0.91) for intracranial aneurysm (unruptured and ruptured combined), 0.57 (95% CI 0.30-1.06) for unruptured intracranial aneurysm, and 0.67 (95% CI 0.48-0.92) for aneurysmal subarachnoid hemorrhage.

CONCLUSION:

This study provides evidence to support that increased serum magnesium concentrations reduce the risk of intracranial aneurysm and associated hemorrhage.

• Authors: Susanna C Larsson, Dipender Gill
• Journal: Neurology (Neurology) Vol. 97 Issue 4 Pg. e341-e344 (07 27 2021) ISSN: 1526-632X [Electronic] United States
• PMID: 34158381 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

Chemical References

• ATP2B1 protein, human
• CNNM2 protein, human
• CNNM4 protein, human
• Cation Transport Proteins
• MDS1 and EVI1 Complex Locus Protein
• Microfilament Proteins
• Mucin-1
• SHROOM3 protein, human
• Plasma Membrane Calcium-Transporting ATPases
• Magnesium

Topics

• Blood Pressure (physiology)
• Case-Control Studies
• Cation Transport Proteins (genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Intracranial Aneurysm (blood, genetics)
• MDS1 and EVI1 Complex Locus Protein (genetics)
• Magnesium (blood)
• Mendelian Randomization Analysis
• Microfilament Proteins (genetics)
• Mucin-1 (genetics)
• Plasma Membrane Calcium-Transporting ATPases (genetics)
• Polymorphism, Single Nucleotide
• Risk Factors