Abstract |
A recent study by Mimouni et al. shows that late gestation exposure to anti-Müllerian hormone (AMH) results in transgenerational transmission of a polycystic ovary syndrome (PCOS)-like phenotype in mice. Altered DNA methylation underlies transmission and was also observed in women with PCOS. Epigenetics-based therapy reversed some PCOS-like phenotypic traits when applied to F3 female mice.
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Authors | Elisabet Stener-Victorin, Qiaolin Deng |
Journal | Trends in molecular medicine
(Trends Mol Med)
Vol. 27
Issue 8
Pg. 723-724
(08 2021)
ISSN: 1471-499X [Electronic] England |
PMID | 34127396
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
Chemical References |
- Androgens
- Biomarkers
- Anti-Mullerian Hormone
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Topics |
- Androgens
(adverse effects, metabolism)
- Anti-Mullerian Hormone
(genetics, metabolism)
- Biomarkers
- Disease Management
- Embryonic Development
- Epigenesis, Genetic
(drug effects)
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Maternal Exposure
- Molecular Targeted Therapy
- Polycystic Ovary Syndrome
(diagnosis, etiology, therapy)
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