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Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance.

Abstract
A recent study by Mimouni et al. shows that late gestation exposure to anti-Müllerian hormone (AMH) results in transgenerational transmission of a polycystic ovary syndrome (PCOS)-like phenotype in mice. Altered DNA methylation underlies transmission and was also observed in women with PCOS. Epigenetics-based therapy reversed some PCOS-like phenotypic traits when applied to F3 female mice.
AuthorsElisabet Stener-Victorin, Qiaolin Deng
JournalTrends in molecular medicine (Trends Mol Med) Vol. 27 Issue 8 Pg. 723-724 (08 2021) ISSN: 1471-499X [Electronic] England
PMID34127396 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Chemical References
  • Androgens
  • Biomarkers
  • Anti-Mullerian Hormone
Topics
  • Androgens (adverse effects, metabolism)
  • Anti-Mullerian Hormone (genetics, metabolism)
  • Biomarkers
  • Disease Management
  • Embryonic Development
  • Epigenesis, Genetic (drug effects)
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Maternal Exposure
  • Molecular Targeted Therapy
  • Polycystic Ovary Syndrome (diagnosis, etiology, therapy)

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