Surgically induced astigmatism following single site and twin site phacotrabeculectomy augmented with mitomycin C.

Abstract

PURPOSE:

To determine difference in surgically induced astigmatism (SIA), post-operative intraocular pressure (IOP) and axial length (AL) between single site and twin-site phacotrabeculectomy augmented with Mitomycin C (MMC).

DESIGN:

Prospective interventional randomised controlled study.

METHODS:

In a prospective interventional comparative study, eligible patients were scheduled for phacotrabeculectomy. They were randomised to either group A: single site or group B: twin-site phacotrabeculectomy with MMC 0.2 mg/mL. Axial length was measured by using Zeiss IOL master I, pre-operatively and at 1, 3, 6 and 12 months post-operatively. Corneal topography was performed using Bausch and Lomb Orbscan I pre-operatively and at 3, 6 and 12 months post-operatively to analyse surgically induced astigmatism. Vector analysis was used to analyse the surgically induced astigmatism.

RESULTS:

One hundred and eight eyes of which 55 patients in group A, and 53 patients in group B were enroled for vector analysis. The mean preoperative astigmatic vector power was +0.89 ± 0.4 D and +0.97 ± 0.5 D in group A and B respectively. The mean post-operative astigmatic vector power was +0.78 ± 0.4 D in group A and +0.96 ± 0.5 D in group B at the end of 12 months. Corneal topography showed post-operative superior flattening (51.8% at 3 months and 55.4% at 12 months) in group A (P = 0.072) compared to superior steepening (59.6% at 3 months and 61.5% at 12 months) in group B (P = 0.977).

CONCLUSIONS:

The two commonly used techniques of combined cataract and glaucoma surgery proved to be efficacious without significant difference in surgical induced astigmatism.

• Authors: Devendra Maheshwari, Ashwin Segi, Sarika Ramugade Shinde, Mohideen Abdul Kader, Ramakrishnan Rengappa
• Journal: Eye (London, England) (Eye (Lond)) Vol. 36 Issue 5 Pg. 1100-1105 (05 2022) ISSN: 1476-5454 [Electronic] England
• PMID: 34117400 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2021. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.

Chemical References

• Mitomycin

Topics

• Astigmatism (drug therapy, etiology)
• Corneal Topography
• Humans
• Mitomycin (therapeutic use)
• Phacoemulsification (adverse effects, methods)
• Prospective Studies