Reasons why COVID-19 survivors should follow dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations: from hyper-inflammation to cardiac dysfunctions.

Abstract

The World Cancer Research Fund and American Institute for Cancer Research (WCRF/AICR) advise cancer survivors to follow their lifestyle recommendations for cancer prevention.  Recent research indicates that a proper diet could exerts beneficial metabolic and immune effects in humans through the involvement of several, not yet properly known, metabolic pathways. Here, we argue that following WCRF/AICR recommendations could be a strategy to prevent cardiovascular outcomes [fulminant myocarditis, heart failure, venous thromboembolism (VTE)] and acute respiratory distress syndrome (ARDS) in patients during follow-up post COVID-19 infection. We discuss the metabolic effects of a WCRF/AICR based diet, highlighting on the involved cardio-metabolic pathways related on NLRP3 inflammasome-cytokines axis aimed to improve prognosis of COVID-19, especially in patients with cancer.

• Authors: V Quagliariello, G D'Aiuto, R V Iaffaioli, M Berretta, S Buccolo, M Iovine, A Paccone, F Cerrone, S Bonanno, G Nunnari, N Laganà, G Botti, N Maurea
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 25 Issue 10 Pg. 3898-3907 (May 2021) ISSN: 2284-0729 [Electronic] Italy
• PMID: 34109598 (Publication Type: Journal Article)

Chemical References

• Cytokines
• NLR Family, Pyrin Domain-Containing 3 Protein

Topics

• Alcohol Drinking
• Body Weight
• COVID-19 (complications, pathology, virology)
• Carbonated Beverages
• Cytokines (metabolism)
• Diet
• Guidelines as Topic
• Humans
• NLR Family, Pyrin Domain-Containing 3 Protein (metabolism)
• Neoplasms (complications, pathology)
• Prognosis
• Red Meat
• Risk Factors
• SARS-CoV-2 (isolation & purification)
• Survivors