Efficacy of Lacosamide in a Patient with Refractory Generalized Epilepsy Based on Video Electroencephalography.

Abstract

A 20-year-old man with drug-resistant generalized epilepsy (GE) was admitted for video electroencephalography (vEEG) monitoring under treatment with multiple antiepileptic drugs, including levetiracetam (3,000 mg/day), valproic acid (800 mg/day), and lacosamide (LCM) (100 mg/day). No seizures were noted after the withdrawal of levetiracetam. However, after the withdrawal of LCM, atypical absence seizures with a 2- to 2.5-Hz generalized spike and wave complex frequently appeared, followed by subsequent generalized-onset tonic-clonic seizures. After re-administration of LCM, the seizures and epileptic discharges clearly disappeared. Subsequent LCM titration was successful in achieving a seizure-free status. Our vEEG results suggest that LCM may be a worthwhile antiepileptic drug adjunct in refractory GE patients without a risk of worsening absence seizures.

• Authors: Hidetada Yamada, Shuichiro Neshige, Takeo Shishido, Hiroki Ueno, Tomohiko Ohshita, Hiroyuki Morino, Hirofumi Maruyama
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 60 Issue 22 Pg. 3621-3624 (Nov 15 2021) ISSN: 1349-7235 [Electronic] Japan
• PMID: 34053987 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Lacosamide

Topics

• Adult
• Anticonvulsants (therapeutic use)
• Electroencephalography
• Epilepsy, Generalized (diagnosis, drug therapy)
• Humans
• Lacosamide (therapeutic use)
• Male
• Seizures (drug therapy)
• Young Adult