Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Postvaccination ASIA Syndrome.

Abstract

CONTEXT:

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome) can be seen as a postvaccination phenomenon that occurs after exposure to adjuvants in vaccines that increase the immune responses. There are very limited data regarding ASIA syndrome following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.

OBJECTIVES:

This work aims to report cases of subacute thyroiditis related to the SARS-CoV-2 vaccine.

METHODS:

We describe the clinical, laboratory, and imaging features of 3 cases of subacute thyroiditis after inactivated SARS-CoV-2 vaccine (CoronaVac®). Three female healthcare workers have applied to our clinic with anterior neck pain and fatigue 4 to 7 days after SARS-CoV-2 vaccination. Two of them were in the breastfeeding period. They were negative for thyroid antibodies, and there was no previous history of thyroid disease, upper respiratory tract infection, or COVID-19. Laboratory test results and imaging findings were consistent with subacute thyroiditis.

RESULTS:

SARS-CoV-2 vaccination can lead to subacute thyroiditis as a phenomenon of ASIA syndrome. Subacute thyroiditis may develop within a few days after the SARS-CoV-2 vaccination. Being in the postpartum period may be a facilitating factor for the development of ASIA syndrome after the SARS-CoV-2 vaccination.

CONCLUSIONS:

This is the first report of subacute thyroiditis as a phenomenon of ASIA syndrome after inactivated COVID-19 vaccination. Clinicians should be aware that subacute thyroiditis may develop as a manifestation of ASIA syndrome after the inactive SARS-CoV-2 vaccine.

• Authors: Burçin Gönül İremli, Süleyman Nahit Şendur, Uğur Ünlütürk
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 106 Issue 9 Pg. 2600-2605 (08 18 2021) ISSN: 1945-7197 [Electronic] United States
• PMID: 34043800 (Publication Type: Case Reports, Journal Article)
• Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• COVID-19 Vaccines

Topics

• Adult
• COVID-19 (prevention & control, virology)
• COVID-19 Vaccines (adverse effects)
• Female
• Health Personnel
• Humans
• Prognosis
• SARS-CoV-2 (isolation & purification)
• Thyroiditis, Subacute (diagnosis, etiology)