Abstract | RATIONALE: Recently, it was found that cyclosomatostatin-induced catalepsy in middle-aged rats is accompanied by neuronal hypoactivation in the lateral entorhinal cortex (LEntCx); this hypoactivation was reversed by systemic administration of nicotine combined with diphenhydramine. These findings suggest the ability of nicotine to regulate catalepsy and the involvement of the LEntCx in this nicotine effect. OBJECTIVES: The study was aimed to assess whether nicotine alone influences catalepsy when injected into the LEntCx and some other neuroanatomical structures. METHODS: Experiments were conducted with male Wistar rats of 540-560 days of age. Catalepsy was induced by intracerebroventricular injection of cyclosomatostatin and assessed by the standard bar test. Nicotine was injected into the LEntCx, prelimbic cortex (PrCx), or basolateral amygdala (BLA). The tissue levels of tyrosine hydroxylase, dopamine, and DOPAC in the substantia nigra pars compacta and dorsal striatum were measured with use of HPLC and ELISA. RESULTS: CONCLUSIONS: This may be the first demonstration of anticataleptic activity of nicotine. The results show that the effect is mediated by nicotine receptors in the LEntCx, via a glutamatergic mechanism. These findings may help advance the development of novel treatments for extrapyramidal disorders, including parkinsonism.
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Authors | Ilya D Ionov, Irina I Pushinskaya, Nicholas P Gorev, David D Frenkel, Nicholas N Severtsev |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 238
Issue 9
Pg. 2471-2483
(09 2021)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 34002247
(Publication Type: Journal Article)
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Copyright | © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Chemical References |
- Dopamine Antagonists
- Nicotine
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Topics |
- Animals
- Catalepsy
(chemically induced, drug therapy)
- Dopamine Antagonists
- Entorhinal Cortex
- Male
- Nicotine
(pharmacology)
- Rats
- Rats, Wistar
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