HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Diphenhydramine (Benadryl)

Subscribe to New Research on Diphenhydramine

A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.

Also Known As:

Benadryl; Diphenhydramine Hydrochloride; Benylin; 2-Diphenylmethoxy-N,N-dimethylethylamine; Allerdryl; Benzhydramine; Dimedrol; Diphenhydramine Citrate; Diphenhydramine Citrate (1:1); Diphenylhydramine; Citrate, Diphenhydramine; Hydrochloride, Diphenhydramine; Benhydramin; Diphenylhydramin; Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-

Networked: 925 relevant articles (83 outcomes, 83 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Ethylamines: 5
    - Diphenhydramine: 925
- Hydrocarbons: 412
  - Cyclic Hydrocarbons: 3
    - Aromatic Hydrocarbons: 132
      - Benzene Derivatives: 13
        Benzhydryl Compounds
        Diphenhydramine: 925
        Dimenhydrinate: 1191
        Mandrax: 21
        embramine: 4
        antigrippen: 1
        bromodiphenhydramine: 1
        embraminteoclat: 1
        peroben: 1
        phenobarbital drug combination diphenydramine cycloclenbutrerol aminophylline: 1
        sagittacin: 1
        Somnium: 1
        desmethyldiphenhydramine
        despa-kowa
        dolo visano
        drug combination pentaerythritol tetranitrate nicotinic acid meprobamate diphenhydramine
        Lomapect
        monodesmethyldiphenhydramine
        moxastine theoclate
        Neo-fluvaleas
        Pellit
        Poly-5
        Propain
        prothidryl
        Sedyn-A-forte

Experts

1.	Gallagher, E John: 6 articles (01/2016 - 06/2006)
2.	Kamei, C: 6 articles (10/2001 - 01/2000)
3.	Solorzano, Clemencia: 5 articles (01/2016 - 06/2006)
4.	Friedman, Benjamin W: 5 articles (01/2016 - 06/2006)
5.	Esses, David: 5 articles (01/2016 - 06/2006)
6.	Kamei, Chiaki: 5 articles (12/2007 - 11/2003)
7.	Bijur, Polly E: 3 articles (01/2016 - 06/2006)
8.	Oyo-Ita, Angela: 3 articles (06/2014 - 01/2012)
9.	Meremikwu, Martin M: 3 articles (06/2014 - 01/2012)
10.	Udoh, Ekong E: 3 articles (06/2014 - 01/2012)

Related Diseases

1.	Vomiting 03/22/2007 - "Diphenhydramine did not significantly reduce emesis induced by any of the challenges (P>0.05). " 01/01/1987 - "Administration of MCP in conjunction with prophylactic diphenhydramine resulted in major antiemetic responses (0-2 episodes of emesis in the 24 h after therapy) in 23 of 33 (70%) patients. " 12/01/1951 - "The intravenous use of diphenhydramine hydrochloride in the control of nausea and vomiting." 10/01/2013 - "Our data showed that antiemetic cocktail containing midazolam and diphenhydramine was not better in controlling acute and delayed emesis. " 01/01/2006 - "13) Following oral exposures of diphenhydramine or dimenhydrinate, do not induce emesis. "
2.	Pruritus (Itching) 03/01/2011 - "Diphenhydramine is a widely used agent for the treatment of urticarial pruritus. " 06/01/2001 - "Pruritus requiring diphenhydramine developed in three patients. " 09/01/1993 - "Minor adverse effects including pruritus occurred in six patients, three of whom required pharmacological intervention with diphenhydramine. " 02/01/1991 - "Diphenhydramine hydrochloride is an antihistamine with anticholinergic properties that is frequently used both orally and topically for the temporary relief of pruritus. " 10/01/1949 - "Control of pruritus with diphenhydramine hydrochloride ointment."
3.	Hypersensitivity (Allergy) 01/01/2010 - "Another patient experienced an allergic reaction at the end of transfusion, which was effectively treated with diphenhydramine. " 03/01/1996 - "The study supports our previous finding that allergy symptoms reduce learning ability which is further reduced learning ability which is further reduced by diphenhydramine. " 06/01/2014 - "Diphenhydramine (DPH) is a first-generation antihistamine, which is useful in treating allergic reaction, and is usually considered innocuous. " 10/01/2008 - "I'm 75, and I've always taken Benadryl for my allergies. " 05/01/2008 - "Diphenhydramine is often the treatment of choice for acute urticarial or allergic reactions despite its adverse effects of sedation and impairment. "
4.	Nausea 12/01/2015 - "Nowadays, diphenhydramine is primarily applied to prevent nausea but also its sedative and analgesic effects are of clinical importance. " 05/01/2013 - "Efficacy of diphenhydramine in the prevention of vertigo and nausea at 7 T MRI." 05/01/2013 - "In this study the potential of diphenhydramine in reducing respectively preventing vertigo and nausea induced by the ultra-high static magnetic field at 7 T was evaluated. " 12/01/1951 - "The intravenous use of diphenhydramine hydrochloride in the control of nausea and vomiting." 03/01/2009 - "The new HG protocol was equivalent to the droperidol and diphenhydramine combination to reduce nausea symptoms, length of hospitalisation (3.7 days vs. 3.1 days), and rate of rehospitalisation for HG (19.23% vs. 24.44%). "
5.	Edema 01/01/1991 - "The edema effect was not antagonized by diphenhydramine." 02/01/1986 - "Diphenhydramine (1.0 X 10(-5) M), a specific H1-histamine receptor antagonist, blocked the increased protein flux that followed PQ administration and significantly delayed edema. " 01/01/2011 - " edema developed 12 hours later and was treated with intravenously administered dexamethasone and diphenhydramine. " 03/01/1989 - "Preliminary administration of dimedrol decreased intensity of the pad edema induced by the antibiotics." 01/01/1985 - "The H1 and H2 receptor blockers (diphenhydramine and cimetidine, respectively) reduced the intensity of capillary engorgement and edema. "

Related Drugs and Biologics

1.	Metoclopramide (Reglan)
2.	Dexamethasone (Maxidex)
3.	Cimetidine (Biomet)
4.	Histamine (Histamine Dihydrochloride)
5.	Cisplatin (Platino)
6.	Substance P
7.	Bradykinin
8.	Dextromethorphan (Levomethorphan)
9.	Lorazepam (Ativan)
10.	Morphine (MS Contin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Premedication
3.	Anesthesia
4.	Long-Term Care
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)