Abstract | BACKGROUND AND AIMS:
Hemorrhagic stroke (HS) results in significant mortality and disability worldwide. Angiotensin Converting Enzyme (ACE) is responsible for blood pressure regulation and vascular homeostasis. Our objective was to conduct a comprehensive meta-analysis for ascertaining the association of ACE I/D polymorphism with HS since a number of studies depicted inconclusive evidence. METHODS: Literature search was performed till July 10, 2020 in PubMed, EMBASE, Cochrane, Chinese National Knowledge Information and Google Scholar databases with keywords: (' Angiotensin Converting Enzyme' OR 'ACE') AND ('Single Nucleotide polymorphisms' OR 'SNP') AND (' Hemorrhagic stroke or 'HS'). Pooled Odds Ratio (OR) and 95% Confidence Interval (CI) were determined for gene-disease association using either fixed (when I2 < 50%) or random effect (when I2 > 50%) models. Risk of bias in studies was assessed using funnel plots and sensitivity analyses. Statistical analysis was performed using STATA version 13.0 software. RESULTS: A total of 53 studies having 5186 HS and 7347 healthy control subjects were included in our meta-analysis. Pooled analyses showed that ACE I/D gene polymorphism had significant association with risk of HS in overall study population [(dominant model: OR = 1.29, 95% CI = 1.12-1.50 & recessive model: OR = 1.79, 95% CI = 1.46-2.20)]. Population subgroup analyses further revealed significant relationship of ACE I/D polymorphism with ICH in Asians (recessive: OR 1.97, 95% CI = 1.57-2.47) but not in Caucasians (recessive: OR 1.02, 95% CI = 0.76-1.36). CONCLUSION: This meta-analysis suggests that ACE I/D polymorphism may lead to risk of HS and can be a potential biomarker for HS susceptibility especially in Asian population.
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Authors | Manabesh Nath, Shubham Misra, Pumanshi Talwar, Deepti Vibha, Achal Kumar Srivastava, Kameshwar Prasad, Pradeep Kumar |
Journal | Gene
(Gene)
Vol. 790
Pg. 145696
(Jul 20 2021)
ISSN: 1879-0038 [Electronic] Netherlands |
PMID | 33964377
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | Copyright © 2021 Elsevier B.V. All rights reserved. |
Chemical References |
- ACE protein, human
- Peptidyl-Dipeptidase A
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Topics |
- Hemorrhagic Stroke
(etiology, pathology)
- Humans
- INDEL Mutation
- Peptidyl-Dipeptidase A
(genetics)
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