Biological functions of IL-17-producing cells in mycoplasma respiratory infection.

Abstract

Mycoplasmas are the smallest and simplest bacteria that lack a cell wall but have the capability of self-replication. Among them, Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia. The hallmark of mycoplasma respiratory diseases is the persistence of lung inflammation that involves both innate and adaptive immune responses. In recent years, a growing body of evidence demonstrates that IL-17 plays an important role in respiratory mycoplasma infection, and associates with the pathologic outcomes of infection, such as pneumonitis and asthma. Numerous studies have shown that a variety of cells, in particular Th17 cells, in the lung can secrete IL-17 during respiratory mycoplasma infection. In this article, we review the biological functions of distinct IL-17-producing cells in mycoplasma respiratory infection with a focus on the effect of IL-17 on the outcomes of infection.

• Authors: Ying Luo, Cheng Li, Zhou Zhou, Zhande Gong, Cuiming Zhu, Aihua Lei
• Journal: Immunology (Immunology) Vol. 164 Issue 2 Pg. 223-230 (10 2021) ISSN: 1365-2567 [Electronic] England
• PMID: 33930194 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2021 John Wiley & Sons Ltd.

Chemical References

• Interleukin-17

Topics

• Animals
• Asthma (immunology)
• Humans
• Interleukin-17 (immunology)
• Lung (immunology)
• Mycoplasma Infections (immunology)
• Mycoplasma pneumoniae (immunology)
• Pneumonia (immunology)
• Respiratory Tract Infections (immunology)